SCHEMBL2457896

SCHEMBL2457896

Cc1ccc(CN2C(=O)C3=C(c4cccc5ccccc45)N(Cc4ccc(C)cc4)C(=O)C3=C2c2cccc3ccccc23)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 1/20 0.47
CLTC Q00610 1/20 0.45
NPSR1 Q6W5P4 1/20 0.44
P2RX4 Q99571 1/20 0.43
CA12 O43570 1/20 0.43
CA9 Q16790 1/20 0.43
MDH2 P40926 1/20 0.42
KDM4E B2RXH2 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
ADRA1D P25100 1/20 0.42
ADRA1A P35348 1/20 0.42
ADRA1B P35368 1/20 0.42
POLB P06746 2/20 0.41
MAPT P10636 2/20 0.41
ALDH1A1 P00352 1/20 0.41
LMNA P02545 1/20 0.41
PABPC1 P11940 1/20 0.40
ALOX15 P16050 1/20 0.40
MAPK1 P28482 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6153269 0.94 GSK3B (0.45) GSK3BCLTCNPSR1P2RX4CA12
SCHEMBL2457775 0.89 NPSR1 (0.56) GSK3BCLTCNPSR1KDM4ESMN1; SMN2
SCHEMBL2457538 0.86 NPSR1 (0.42) GSK3BNPSR1CA12CA9KDM4E
SCHEMBL10086968 0.85 P2RX4 (0.43) GSK3BCLTCP2RX4CA12CA9
SCHEMBL6153208 0.85 RGS4 (0.47) P2RX4CA12CA9MDH2SMN1; SMN2
SCHEMBL2457350 0.84 RGS4 (0.41) GSK3BCLTCP2RX4CA12CA9
SCHEMBL2457833 0.80 CYP1B1 (0.51) NPSR1KDM4ESMN1; SMN2POLBMAPT
SCHEMBL8737445 0.76 CASP3 (0.65) NPSR1CA12CA9ADRA1DADRA1A
SCHEMBL29820192 0.76 CASP3 (0.65) NPSR1CA12CA9ADRA1DADRA1A
SCHEMBL1719186 0.72 CYP1B1 (0.50) CA12CA9POLBMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1341403-B1 LUMINESCENT ELEMENT MATERIAL AND LUMINESCENT ELEMENT COMPRISING THE SAME TORAY INDUSTRIES (JP) 2016-05-11 EP disclosed
EP-2365735-B1 Luminescent element material and luminescent element comprising the same TORAY INDUSTRIES (JP) 2013-08-28 EP disclosed
EP-2365735-A2 Luminescent element material and luminescent element comprising the same TORAY INDUSTRIES INC. (JP) 2011-09-14 EP disclosed
US-7318966-B2 Luminescent element material and luminescent element comprising the same TORAY INDUSTRIES, INC. (JP) 2008-01-15 US disclosed
US-20030168970-A1 Luminescent element material and luminescent element comprising the same TORAY INDUSTRIES, INC. (JP) 2003-09-11 US disclosed
EP-1341403-A1 LUMINESCENT ELEMENT MATERIAL AND LUMINESCENT ELEMENT COMPRISING THE SAME Toray Industries, Inc. (JP) 2003-09-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030168970-A1 Luminescent element material and luminescent element comprising the same SAAL1, EBPL, CSNK1A1L GSK3B 3346/4885CLTC 2546/4885NPSR1 1111/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.