Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Codeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 0.93 |
| ▸ | OPRD1 known ✓ | P41143 | 8/20 | 0.91 |
| ▸ | OPRK1 known ✓ | P41145 | 5/20 | 0.91 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.91 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.91 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.91 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.91 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL1275480 | 1.00 | OPRM1 (0.93) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL29409567 | 1.00 | OPRM1 (0.93) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL24578 | 0.99 | OPRD1 (0.93) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL24580 | 0.99 | OPRD1 (0.93) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3031563 | 0.96 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL7632902 | 0.96 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL29938690 | 0.96 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL7936660 | 0.95 | OPRD1 (0.86) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL9324126 | 0.95 | OPRM1 (0.98) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL12638890 | 0.95 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102740854-A | Loxoprofen-containing pharmaceutical composition | KOWA CO | 2012-10-17 | — | — | CN | claimed |
| EP-4393512-B1 | COMPOSITION FOR PHARMACEUTICAL TABLET, PHARMACEUTICAL TABLET USING THE SAME, AND MANUFACTURING METHOD THEREOF | MITSUBISHI CHEM CORP (JP) | 2025-10-01 | — | — | EP | disclosed |
| WO-2025105451-A1 | SOLID PREPARATION | 第一三共ヘルスケア株式会社 | 2025-05-22 | — | — | WO | disclosed |
| WO-2025100523-A1 | METHOD FOR PRODUCING SOLID PREPARATION, AND TABLETS | 第一三共ヘルスケア株式会社 | 2025-05-15 | — | — | WO | disclosed |
| US-20250115919-A1 | COMPOSITIONS AND METHODS RELATED TO APTAMER-BASED COLORIMETRIC ASSAYS | NORTH CAROLINA STATE UNIVERSITY | 2025-04-10 | — | — | US | disclosed |
| CN-119278035-A | Solid preparation and method for producing the same | 第一三共健康事业株式会社 | 2025-01-07 | — | — | CN | disclosed |
| CN-113038933-B | Oral pharmaceutical preparation containing ibuprofen | SS制药株式会社 | 2024-11-12 | — | — | CN | disclosed |
| EP-4393512-A1 | COMPOSITION FOR MEDICINAL TABLET, MEDICINAL TABLET OBTAINED USING SAME, AND PRODUCTION METHOD THEREFOR | Mitsubishi Chemical Corporation (JP) | 2024-07-03 | — | — | EP | disclosed |
| US-20240173260-A1 | COMPOSITION FOR PHARMACEUTICAL TABLET, PHARMACEUTICAL TABLET USING THE SAME, AND MANUFACTURING METHOD THEREOF | MITSUBISHI CHEMICAL CORPORATION (JP) | 2024-05-30 | — | — | US | disclosed |
| CN-117836005-A | Composition for pharmaceutical tablet, pharmaceutical tablet using the same, and method for producing the same | 三菱化学株式会社 | 2024-04-05 | — | — | CN | disclosed |
| EP-2554164-A1 | PHARMACEUTICAL FORMULATION BASED ON IBUPROFEN AND CODEINE HAVING HAVING IMPROVED STABILITY | Farmasierra Manufacturing, S.L. (ES) | 2013-02-06 | — | — | EP | disclosed |
| CN-102740854-A | Loxoprofen-containing pharmaceutical composition | KOWA CO | 2012-10-17 | — | — | CN | disclosed |
| US-20120165413-A1 | DISINTEGRATING PARTICLE COMPOSITION AND ORALLY RAPIDLY DISINTEGRATING TABLET | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 2012-06-28 | — | — | US | disclosed |
| US-20120156261-A1 | DISINTEGRATING PARTICLE COMPOSITION AND ORALLY RAPIDLY DISINTEGRATING TABLET | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 2012-06-21 | — | — | US | disclosed |
| EP-2465539-A1 | DISINTEGRATING PARTICLE COMPOSITION AND ORALLY RAPIDLY DISINTEGRATING TABLET | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 2012-06-20 | — | — | EP | disclosed |
| EP-2465540-A1 | DISINTEGRATING PARTICLE COMPOSITION AND ORALLY RAPIDLY DISINTEGRATING TABLET | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 2012-06-20 | — | — | EP | disclosed |
| US-8034801-B2 | Analgesic agent | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2011-10-11 | — | — | US | disclosed |
| US-20090253729-A1 | Analgesic Agent | ASKA PHARMACEUTICAL CO., LTD. (JP) | 2009-10-08 | — | — | US | disclosed |
| EP-2039359-A1 | ANALGESIC AGENT | ASKA Pharmaceutical Co., Ltd. (JP) | 2009-03-25 | — | — | EP | disclosed |
| US-7008939-B2 | Use of weak opioids and mixed opioid agonists/antagonists for treatment of urinary incontinence | GRUENENTHAL GMBH (DE) | 2006-03-07 | — | — | US | disclosed |