Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Codeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 7/20 | 0.93 |
| ▸ | OPRD1 known ✓ | P41143 | 8/20 | 0.91 |
| ▸ | OPRK1 known ✓ | P41145 | 5/20 | 0.91 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.91 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.91 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.91 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.91 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL29409567 | 1.00 | OPRM1 (0.93) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL2515523 | 1.00 | OPRM1 (0.93) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL24578 | 0.99 | OPRD1 (0.93) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL24580 | 0.99 | OPRD1 (0.93) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3031563 | 0.96 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL29938690 | 0.96 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL7632902 | 0.96 | OPRM1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL7936660 | 0.95 | OPRD1 (0.86) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL9324126 | 0.95 | OPRM1 (0.98) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL1560699 | 0.95 | OPRD1 (1.00) | OPRM1OPRD1OPRK1MRGPRX2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4389120-A1 | AN ANTI-INFLAMMATORY PHARMACEUTICAL COMPOSITION | Inflacod Sp. z o.o. (PL) | 2024-06-26 | — | — | EP | claimed |
| CN-115057865-B | Preparation method of codeine phosphate hemihydrate | 国药集团工业有限公司 | 2023-03-31 | — | — | CN | claimed |
| CN-115057865-A | Preparation method of codeine phosphate hemihydrate | 国药集团工业有限公司 | 2022-09-16 | — | — | CN | claimed |
| US-8491930-B2 | Pharmaceutical formulation containing ibuprofen and codeine | FARMASIERRA MANUFACTURING, S.L. (ES) | 2013-07-23 | — | — | US | claimed |
| EP-2279731-B1 | IMPROVED PHARMACEUTICAL COMPOSITION CONTAINING IBUPROFEN AND CODEINE | FARMASIERRA MFG S L (ES) | 2012-12-12 | — | — | EP | claimed |
| US-20110293716-A1 | PHARMACEUTICAL FORMULATION CONTAINING IBUPROFEN AND CODEINE | FARMASIERRA MANUFACTURING, S.L. (ES) | 2011-12-01 | — | — | US | claimed |
| EP-2279731-A1 | IMPROVED PHARMACEUTICAL COMPOSITION CONTAINING IBUPROFEN AND CODEINE | Farmasierra Manufacturing, S.L. (ES) | 2011-02-02 | — | — | EP | claimed |
| EP-0777477-B1 | IMPROVED PHARMACEUTICAL FORMULATIONS CONTAINING IBUPROFEN AND CODEINE | SMITHKLINE BEECHAM PLC (GB) | 2002-11-13 | — | — | EP | claimed |
| EP-0777477-A1 | IMPROVED PHARMACEUTICAL FORMULATIONS CONTAINING IBUPROFEN AND CODEINE | SMITHKLINE BEECHAM PLC (GB) | 1997-06-11 | — | — | EP | claimed |
| WO-1996005834-A1 | IMPROVED PHARMACEUTICAL FORMULATIONS CONTAINING IBUPROFEN AND CODEINE | SMITHKLINE BEECHAM PLC (GB) | 1996-02-29 | — | — | WO | claimed |
| EP-3824878-B1 | ABUSE RESISTANT CAPSULE | SCHERER TECHNOLOGIES LLC R P (US) | 2025-11-12 | — | — | EP | disclosed |
| US-12133922-B2 | Abuse resistant capsule | R.P. SCHERER TECHNOLOGIES, LLC (US) | 2024-11-05 | — | — | US | disclosed |
| EP-4389120-A1 | AN ANTI-INFLAMMATORY PHARMACEUTICAL COMPOSITION | Inflacod Sp. z o.o. (PL) | 2024-06-26 | — | — | EP | disclosed |
| CN-115057865-B | Preparation method of codeine phosphate hemihydrate | 国药集团工业有限公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-115057865-B | Preparation method of codeine phosphate hemihydrate | 国药集团工业有限公司 | 2023-03-31 | — | — | CN | disclosed |
| US-6024982-A | TABLET DISINTEGRATION | EURO-CELTIQUE, S.A. (LU) | 2000-02-15 | — | — | US | disclosed |
| EP-0777477-A1 | IMPROVED PHARMACEUTICAL FORMULATIONS CONTAINING IBUPROFEN AND CODEINE | SMITHKLINE BEECHAM PLC (GB) | 1997-06-11 | — | — | EP | disclosed |
| US-5500227-A | Immediate release tablet cores of insoluble drugs having sustained-release coating | EURO-CELTIQUE, S.A. (LU) | 1996-03-19 | — | — | US | disclosed |
| WO-1996005834-A1 | IMPROVED PHARMACEUTICAL FORMULATIONS CONTAINING IBUPROFEN AND CODEINE | SMITHKLINE BEECHAM PLC (GB) | 1996-02-29 | — | — | WO | disclosed |
| EP-0655240-A2 | Immediate release tablet cores of insoluble drugs having substained-release coating | Euroceltique S.A. (LU) | 1995-05-31 | — | — | EP | disclosed |