Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 7/20 | 0.56 |
| ▸ | CDK9 | P50750 | 1/20 | 0.54 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | AKT2 | P31751 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 4/20 | 0.47 |
| ▸ | HIPK1 | Q86Z02 | 4/20 | 0.47 |
| ▸ | HIPK2 | Q9H2X6 | 4/20 | 0.47 |
| ▸ | HIPK3 | Q9H422 | 4/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 6/20 | 0.47 |
| ▸ | CA12 | O43570 | 4/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2459814 | 0.87 | AKT2 (0.47) | DYRK1ACDK9AKT1AKT2CLK2 | |
| SCHEMBL21359203 | 0.77 | MIF (0.48) | CLK2HIPK1HIPK2HIPK3CLK4 | |
| SCHEMBL2458123 | 0.77 | CLK2 (0.44) | DYRK1AAKT1AKT2CLK2HIPK1 | |
| SCHEMBL30423371 | 0.76 | AKT2 (0.54) | DYRK1AAKT1AKT2CLK2HIPK1 | |
| SCHEMBL17226522 | 0.75 | DYRK1A (0.54) | DYRK1AAKT1AKT2CLK2HIPK1 | |
| SCHEMBL2462244 | 0.72 | DYRK1A (0.54) | DYRK1ACDK9CA2CA12KMO | |
| SCHEMBL1602484 | 0.72 | DYRK1A (0.69) | DYRK1ACDK9CA2CA12KMO | |
| SCHEMBL2465313 | 0.72 | DYRK1A (0.54) | DYRK1AAKT1AKT2CLK2HIPK1 | |
| SCHEMBL30424015 | 0.72 | AKT2 (0.71) | DYRK1AAKT1AKT2CLK2HIPK1 | |
| SCHEMBL6829643 | 0.72 | DYRK1A (1.00) | DYRK1ACDK9CA2CA12KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237633-A1 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2011-09-29 | — | — | US | disclosed |
| WO-2010068287-A2 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237633-A1 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, MET | DYRK1A 4134/4885CDK9 3284/4885AKT1 248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.