Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CCR2 | P41597 | 3/20 | 0.44 |
| ▸ | ALKBH3 | Q96Q83 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2459259 | 0.89 | CCR2 (0.51) | CCR2ALKBH3 | |
| SCHEMBL2456787 | 0.89 | CCR2 (0.43) | THRBKDM4ECCR2ALKBH3NR3C1 | |
| SCHEMBL2454543 | 0.89 | ADCY10 (0.44) | KDM4ECCR2ALKBH3HTR6ENPP1 | |
| SCHEMBL12324673 | 0.87 | IDH1 (0.47) | CCR2HTR6ENPP1 | |
| SCHEMBL12324736 | 0.86 | CCR2 (0.46) | CCR2ALKBH3NR3C1MPODAO | |
| SCHEMBL2457171 | 0.83 | ALKBH3 (0.48) | CCR2ALKBH3HTR6ALDH1A1 | |
| SCHEMBL2461969 | 0.83 | PNP (0.39) | KDM4EALDH1A1 | |
| SCHEMBL2462018 | 0.82 | PDE10A (0.40) | KDM4EALKBH3ALDH1A1TDP1 | |
| SCHEMBL12324671 | 0.81 | PARP14 (0.42) | KDM4EALKBH3ALDH1A1 | |
| SCHEMBL2464343 | 0.81 | ALKBH3 (0.40) | KDM4ECCR2ALKBH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |