Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 3/20 | 0.43 |
| ▸ | ALKBH3 | Q96Q83 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2463316 | 0.89 | THRB (0.46) | CCR2ALKBH3THRBKDM4EALDH1A1 | |
| SCHEMBL2459259 | 0.87 | CCR2 (0.51) | CCR2ALKBH3 | |
| SCHEMBL2454543 | 0.87 | ADCY10 (0.44) | CCR2ALKBH3HPGDL3MBTL1KDM4E | |
| SCHEMBL2464343 | 0.86 | ALKBH3 (0.40) | CCR2ALKBH3POLBTSHRHPGD | |
| SCHEMBL2425276 | 0.86 | KDM4E (0.46) | ALKBH3HPGDKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12324673 | 0.85 | IDH1 (0.47) | CCR2 | |
| SCHEMBL12324736 | 0.84 | CCR2 (0.46) | CCR2ALKBH3MAPTNR3C1 | |
| SCHEMBL2461969 | 0.81 | PNP (0.39) | HPGDMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2457171 | 0.81 | ALKBH3 (0.48) | CCR2ALKBH3POLBHPGDMEN1 | |
| SCHEMBL2462018 | 0.80 | PDE10A (0.40) | ALKBH3HPGDMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |