Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | GABRE | P78334 | 1/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.37 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KRAS | P01116 | 2/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.34 |
| ▸ | PTGES | O14684 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14134348 | 0.83 | P2RX3 (0.38) | GABRA1GABRB1GABRPGABRDGABRG2 | |
| SCHEMBL170307 | 0.80 | GABRA1 (0.41) | GABRA1GABRB1GABRPGABRDGABRG2 | |
| SCHEMBL23083124 | 0.79 | ALDH1A1 (0.39) | GABRA1GABRB1GABRPGABRDGABRG2 | |
| SCHEMBL24045130 | 0.78 | KRAS (0.38) | GABRA1GABRB1GABRPGABRDGABRG2 | |
| SCHEMBL172311 | 0.77 | AOC3 (0.40) | GABRA1GABRB1GABRPGABRDGABRG2 | |
| SCHEMBL13765680 | 0.77 | GABRP (0.39) | GABRA1GABRB1GABRPGABRDGABRG2 | |
| SCHEMBL11641291 | 0.76 | MAPT (0.40) | GABRA1GABRB1GABRPGABRDGABRG2 | |
| SCHEMBL20642297 | 0.76 | LMNA (0.32) | GABRA1GABRB1THRATHRBP2RX3 | |
| SCHEMBL2737360 | 0.74 | GABRA1 (0.37) | GABRA1GABRB1P2RX3P2RX2LMNA | |
| SCHEMBL17494708 | 0.73 | MAPT (0.38) | GABRA1GABRB1GABRPGABRDGABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022140169-A1 | PREPARATION OF TETRAHYDROINDAZOLE DERIVATIVES AS NOVEL DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2022-06-30 | — | — | WO | disclosed |