Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 8/20 | 0.48 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 4/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | STK4 | Q13043 | 1/20 | 0.35 |
| ▸ | STK3 | Q13188 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2424473 | 0.86 | NR3C1 (0.48) | NR3C1NR3C2PGRCCR2ENPP1 | |
| SCHEMBL2468099 | 0.85 | NR3C1 (0.48) | NR3C1NR3C2PGRCCR2ENPP1 | |
| SCHEMBL2465404 | 0.84 | NR3C1 (0.47) | NR3C1NR3C2PGRCCR2CNR2 | |
| SCHEMBL2458512 | 0.83 | NR3C1 (0.51) | NR3C1NR3C2PGRCCR2ENPP1 | |
| SCHEMBL2456565 | 0.79 | CCR2 (0.50) | NR3C1NR3C2PGRCCR2ENPP1 | |
| SCHEMBL2459450 | 0.78 | ENPP1 (0.47) | CCR2ENPP1CCR5PDE1B | |
| SCHEMBL2455177 | 0.77 | NR3C1 (0.46) | NR3C1NR3C2PGRCCR2ENPP1 | |
| SCHEMBL2456663 | 0.77 | CCR2 (0.48) | NR3C1NR3C2PGRCCR2ENPP1 | |
| SCHEMBL2460219 | 0.77 | CCR2 (0.46) | NR3C1NR3C2PGRCCR2ENPP1 | |
| SCHEMBL2457283 | 0.76 | ENPP1 (0.46) | NR3C1CCR2ENPP1CCR5PDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |