Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 4/20 | 0.48 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2424473 | 0.99 | NR3C1 (0.48) | NR3C1NR3C2PGRENPP1CCR2 | |
| SCHEMBL2465404 | 0.91 | NR3C1 (0.47) | NR3C1NR3C2PGRENPP1CCR2 | |
| SCHEMBL2458512 | 0.90 | NR3C1 (0.51) | NR3C1NR3C2PGRENPP1CCR2 | |
| SCHEMBL2427055 | 0.85 | PDE2A (0.37) | NR3C1NR3C2PGRPIK3CAPIK3CB | |
| SCHEMBL2459604 | 0.85 | NR3C1 (0.48) | NR3C1NR3C2PGRENPP1CCR2 | |
| SCHEMBL2459450 | 0.82 | ENPP1 (0.47) | ENPP1CCR2CCR5ALKBH3PDE1B | |
| SCHEMBL2457283 | 0.81 | ENPP1 (0.46) | NR3C1ENPP1CCR2CCR5ALKBH3 | |
| SCHEMBL2455657 | 0.81 | ENPP1 (0.50) | NR3C1ENPP1CCR2MEN1ALDH1A1 | |
| SCHEMBL2458532 | 0.80 | ENPP1 (0.45) | NR3C1NR3C2PGRENPP1CCR2 | |
| SCHEMBL2460219 | 0.80 | CCR2 (0.46) | NR3C1NR3C2PGRENPP1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | claimed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |
| WO-2011114148-A1 | 4H- [1, 2, 4] TRIAZOLO [5, 1 -B] PYRIMIDIN-7 -ONE DERIVATIVES AS CCR2B RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2011-09-22 | — | — | WO | disclosed |