Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1408791 | 0.75 | ALDH1A1 (0.39) | KDM4EALDH1A1GAATDP1TSHR | |
| SCHEMBL2460600 | 0.75 | ALDH1A1 (0.37) | KDM4EALDH1A1GAAHPGDLMNA | |
| SCHEMBL9241404 | 0.72 | KDM4E (0.49) | KDM4EALDH1A1GAAHPGDLMNA | |
| SCHEMBL15632407 | 0.72 | KIF11 (0.49) | KDM4EALDH1A1GAAHPGDLMNA | |
| SCHEMBL1408377 | 0.71 | MAPT (0.37) | ALDH1A1HPGDMEN1KMT2ATDP1 | |
| SCHEMBL31614360 | 0.71 | ALDH1A1 (0.41) | KDM4EALDH1A1GAAHPGDLMNA | |
| SCHEMBL17988784 | 0.71 | MEN1 (0.38) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2763850 | 0.71 | ALDH1A1 (0.35) | KDM4EALDH1A1L3MBTL1TDP1TSHR | |
| SCHEMBL12776571 | 0.71 | CYP2A6 (0.42) | KDM4EALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL20426217 | 0.70 | KDM4E (0.49) | KDM4EALDH1A1GAAHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1034221-B1 | DIBENZORHODAMINE DYES USEFUL AS FLUORESCENT LABELLING AGENTS | LIFE TECHNOLOGIES CORP (US) | 2014-05-14 | — | — | EP | disclosed |
| US-20110124510-A1 | METHODS OF LABELING POLYNUCLEOTIDE WITH DIBENZORHODAMINE DYES | Life Technologies Corporation (US) | 2011-05-26 | — | — | US | disclosed |
| EP-2295503-A1 | Dibenzorhodamine dyes useful as fluorescent labelling agents | Applera Corporation (US) | 2011-03-16 | — | — | EP | disclosed |
| US-7833756-B2 | Methods of labelling polynucleotides with dibenzorhodamine dyes | APPLIED BIOSYSTEMS, LLC (US) | 2010-11-16 | — | — | US | disclosed |
| EP-2221347-A1 | Sulfonated diarylrhodamine dyes | Applera Corporation (US) | 2010-08-25 | — | — | EP | disclosed |
| EP-2186801-A2 | Intermediates for synthesizing dibenzorhodamine dyes | Applera Corporation (US) | 2010-05-19 | — | — | EP | disclosed |
| EP-2179996-A1 | Sulfonated diarylrhodamine dyes | Applera Corporation (US) | 2010-04-28 | — | — | EP | disclosed |
| US-20090068751-A1 | Methods of Labelling Polynucleotides with Dibenzorhodamine Dyes | APPLIED BIOSYSTEMS INC. (US) | 2009-03-12 | — | — | US | disclosed |
| US-7018431-B2 | Sulfonated diarylrhodamine dyes | APPLERA CORPORATION (US) | 2006-03-28 | — | — | US | disclosed |
| US-20060051791-A1 | Methods of labelling polynucleotides with dibenzorhodamine dyes | APPLERA CORPORATION (US) | 2006-03-09 | — | — | US | disclosed |
| WO-2002044416-A2 | SULFONATED DIARYLRHODAMINE DYES AS FLUORESCENT LABELS | APPLERA CORPORATION (US) | 2002-06-06 | — | — | WO | disclosed |
| US-20020034761-A1 | Methods of labelling polynucleotides with dibenzorhodamine dyes | THE PERKIN-ELMER CORPORATION (US) | 2002-03-21 | — | — | US | disclosed |
| US-6326153-B2 | POLYNUCLEOTIDE SEQUENCING | THE PERKIN-ELMER CORPORATION | 2001-12-04 | — | — | US | disclosed |
| US-20010011139-A1 | Polynucleotides labeled with dibenzorhodamine dyes | THE PERKIN-ELMER CORPORATION | 2001-08-02 | — | — | US | disclosed |
| US-6221606-B1 | ENERGY TRANSFER DYE COMPRISING A DONOR DYE WHICH ABSORBS IGHT AND EMITS EXITATION ENERGY, AN ACCEPTOR DYE THE ABSORBS THE EXCITATION ENERGY AND FLUORESCES IN RESPONSE, AND A LINKER LINKING THE TWO DYES, AT LEAST ONE IS A DIBENZORHODAMINE DYE | THE PERKIN-ELMER CORPORATION | 2001-04-24 | — | — | US | disclosed |
| EP-1034221-A1 | DIBENZORHODAMINE DYES USEFUL AS FLUORESCENT LABELLING AGENTS | THE PERKIN-ELMER CORPORATION (US) | 2000-09-13 | — | — | EP | disclosed |
| US-6111116-A | FLUORESCENT LABELING REAGENTS | THE PERKIN-ELMER CORPORATION (US) | 2000-08-29 | — | — | US | disclosed |
| US-6051719-A | FLUORESCENT LABELING REAGENTS | THE PERKIN-ELMER CORPORATION (US) | 2000-04-18 | — | — | US | disclosed |
| US-5936087-A | FLUORESCENT LABELS; DNA SEQUENCING | THE PERKIN-ELMER CORPORATION (US) | 1999-08-10 | — | — | US | disclosed |
| WO-1999027020-A1 | DIBENZORHODAMINE DYES USEFUL AS FLOURESCENT LABELLING AGENTS | THE PERKIN-ELMER CORPORATION (US) | 1999-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020034761-A1 | Methods of labelling polynucleotides with dibenzorhodamine dyes | NUDT1, DUT, NSUN2 | KDM4E 3960/4885ALDH1A1 1831/4885GAA 2920/4885 |
| US-20010011139-A1 | Polynucleotides labeled with dibenzorhodamine dyes | NUDT1, DNTT, DUT | KDM4E 4648/4885ALDH1A1 1223/4885GAA 1445/4885 |
| US-20060051791-A1 | Methods of labelling polynucleotides with dibenzorhodamine dyes | NUDT1, DUT, NSUN3 | KDM4E 3602/4885ALDH1A1 1629/4885GAA 2790/4885 |
| US-20090068751-A1 | Methods of Labelling Polynucleotides with Dibenzorhodamine Dyes | NUDT1, DUT, NSUN3 | KDM4E 3602/4885ALDH1A1 1629/4885GAA 2790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.