Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30109383 | 0.99 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL8068701 | 0.87 | NPC1 (0.67) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL29618182 | 0.86 | RAB9A (0.64) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL13648647 | 0.86 | RAB9A (0.64) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL30343291 | 0.84 | NPC1 (0.65) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL599994 | 0.84 | NPC1 (0.65) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL11694301 | 0.83 | NPC1 (0.62) | ALDH1A1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL12216699 | 0.82 | NPC1 (0.60) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| Bromide SCHEMBL5144105 | 0.82 | NPC1 (0.61) | ALDH1A1MEN1KMT2ASMN1; SMN2RAB9A | |
| Hydrochloric Acid SCHEMBL2259707 | 0.82 | NPC1 (0.49) | ALDH1A1MEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8014056-B2 | Display element and method of driving the same | KONICA MINOLTA HOLDINGS, INC. (JP) | 2011-09-06 | — | — | US | disclosed |
| US-20100091353-A1 | DISPLAY ELEMENT AND METHOD OF DRIVING THE SAME | KONICA MINOLTA HOLDINGS, INC. (JP) | 2010-04-15 | — | — | US | disclosed |
| EP-2096490-A1 | DISPLAY ELEMENT AND METHOD OF DRIVING THE SAME | Konica Minolta Holdings, Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |