Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2432181 | 0.78 | HPGD (0.43) | TNKSPARP1TNKS2CYP1A1CYP1A2 | |
| SCHEMBL1136167 | 0.73 | MAOB (0.39) | PTGS2L3MBTL1 | |
| SCHEMBL1136308 | 0.73 | MAOB (0.39) | MAPTPOLBHPGDPTGS2ATM | |
| SCHEMBL2434710 | 0.72 | KDM4E (0.44) | KDM4EHPGDALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL2458247 | 0.71 | ALDH1A1 (0.40) | TNKSKDM4EMAPTLMNAHPGD | |
| SCHEMBL2581501 | 0.71 | ERN1 (0.38) | PTGS2 | |
| SCHEMBL2492254 | 0.71 | MAOB (0.37) | PTGS2 | |
| SCHEMBL1136363 | 0.71 | MAOB (0.37) | KDM4EMAPTBLMALDH1A1PTGS2 | |
| SCHEMBL1136380 | 0.71 | MAOB (0.39) | PTGS2 | |
| SCHEMBL2461285 | 0.70 | PTGS2 (0.40) | KDM4EALDH1A1PTGS2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364298-A1 | Quinolone compound and pharmaceutical composition | Otsuka Pharmaceutical Co., Ltd. (JP) | 2011-09-14 | — | — | EP | disclosed |