SCHEMBL24642860

SCHEMBL24642860

CC(C)[C@H](NC(=O)CCCC#Cc1cnc(S(C)(=O)=O)nc1)C(=O)N[C@@H](CCCCNC(=O)OC(C)(C)C)C(=O)O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA2 P00918 4/20 0.36
▸ CA1 P00915 3/20 0.36
▸ TDP1 Q9NUW8 6/20 0.36
▸ ATM Q13315 2/20 0.36
▸ MAPT P10636 4/20 0.36
▸ NPSR1 Q6W5P4 7/20 0.35
▸ MEN1 O00255 4/20 0.35
▸ KMT2A Q03164 4/20 0.35
▸ POLB P06746 3/20 0.35
▸ ALDH1A1 P00352 2/20 0.35
▸ TSHR P16473 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ CTSS P25774 1/20 0.35
▸ CTSK P43235 1/20 0.35
▸ ITGB1 P05556 1/20 0.34
▸ ITGA4 P13612 1/20 0.34
▸ SDCBP O00560 1/20 0.34
▸ SDC2 P34741 1/20 0.34
▸ PAX8 Q06710 1/20 0.34
▸ SUCNR1 Q9BXA5 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24642846 0.95 CAPN1 (0.39) CA2CA1TDP1ATMMEN1
SCHEMBL24642859 0.89 TDP1 (0.36) CA2CA1TDP1ATMMAPT
SCHEMBL24642833 0.84 MMP2 (0.33) ITGB1ITGA4
SCHEMBL30604911 0.82 MMP2 (0.32) CA2CA1
SCHEMBL24642682 0.82 MMP2 (0.32) —
SCHEMBL26528748 0.82 NOD1 (0.32) —
SCHEMBL31538101 0.81 GLP1R (0.39) TDP1ATMMAPTNPSR1MEN1
SCHEMBL26527755 0.81 GLP1R (0.39) TDP1ATMMAPTNPSR1MEN1
SCHEMBL26528590 0.81 TDP1 (0.40) TDP1ATMMAPTNPSR1MEN1
SCHEMBL30604905 0.81 GLP1R (0.39) TDP1ATMMAPTNPSR1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4748843-A2 ANTIBODY-DRUG CONJUGATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF Medilink Therapeutics (Suzhou) Co., Ltd. (CN) 2026-05-27 — — EP disclosed
EP-4556026-A1 ANTIBODY-DRUG CONJUGATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF Medilink Therapeutics (Suzhou) Co., Ltd. (CN) 2025-05-21 — — EP disclosed
EP-4552654-A1 ANTIBODY-DRUG CONJUGATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF Medilink Therapeutics (Suzhou) Co., Ltd. (CN) 2025-05-14 — — EP disclosed
US-20250144229-A1 CONJUGATE OF ANTIBODY-ERIBULIN OR DERIVATIVE THEREOF, INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF MEDILINK THERAPEUTICS (SUZHOU) CO., LTD. (CN) 2025-05-08 — — US disclosed
EP-4480499-A1 CONJUGATE OF ANTIBODY-ERIBULIN OR DERIVATIVE THEREOF, INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF Medilink Therapeutics (Suzhou) Co., Ltd. (CN) 2024-12-25 — — EP disclosed
US-20240108745-A1 BIOACTIVE SUBSTANCE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF MEDILINK THERAPEUTICS (SUZHOU) CO., LTD. (CN) 2024-04-04 — — US disclosed
EP-4257154-A1 BIOACTIVE SUBSTANCE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF Medilink Therapeutics (Suzhou) Co., Ltd. (CN) 2023-10-11 — — EP disclosed
EP-4257154-A1 BIOACTIVE SUBSTANCE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF Medilink Therapeutics (Suzhou) Co., Ltd. (CN) 2023-10-11 — — EP disclosed
WO-2022170971-A1 BIOACTIVE SUBSTANCE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF 苏州宜联生物医药有限公司 2022-08-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250144229-A1 CONJUGATE OF ANTIBODY-ERIBULIN OR DERIVATIVE THEREOF, INTERMEDIATE THEREOF, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF ERLIN1, WEE1, ERLIN2 CA2 4367/4885CA1 2573/4885TDP1 3976/4885
US-20240108745-A1 BIOACTIVE SUBSTANCE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF CTSL, VIP, FURIN CA2 4620/4885CA1 3250/4885TDP1 3554/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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