Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4811149 | 1.00 | ALOX15 (0.57) | ALOX15AOC3ALDH1A1MAPTHPGD | |
| SCHEMBL10665829 | 0.85 | L3MBTL1 (0.56) | ALOX15ALDH1A1MAPTHPGDTHRB | |
| SCHEMBL9391256 | 0.85 | HPGD (0.57) | ALOX15HPGDTHRBL3MBTL1HTT | |
| SCHEMBL16509661 | 0.85 | ALOX15 (0.55) | ALOX15ALDH1A1MAPTHPGDTHRB | |
| SCHEMBL13573006 | 0.85 | ALOX15 (0.55) | ALOX15ALDH1A1MAPTHPGDTHRB | |
| SCHEMBL12430380 | 0.85 | ALOX15 (0.55) | ALOX15ALDH1A1MAPTHPGDTHRB | |
| SCHEMBL5468798 | 0.85 | AOC3 (0.57) | AOC3ALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL7644842 | 0.84 | LMNA (0.47) | ALOX15ALDH1A1MAPTHPGDKDM4E | |
| SCHEMBL8770968 | 0.84 | SMN1; SMN2 (0.50) | ALOX15ALDH1A1HPGDTHRBL3MBTL1 | |
| SCHEMBL4497426 | 0.83 | KMT2A (0.49) | ALOX15ALDH1A1MAPTKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235866-A1 | COVALENT RAS INHIBITORS AND USES THEREOF | Revolution Medicines, Inc. (US) | 2022-11-10 | — | — | WO | disclosed |