Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2467176 | 0.89 | PKM (0.41) | CNR2BRD4PKMCNR1JAK2 | |
| SCHEMBL2471273 | 0.87 | CNR2 (0.45) | CNR2BRD4JAK2LMNA | |
| SCHEMBL141784 | 0.73 | JAK2 (0.67) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL2472271 | 0.71 | GRM2 (0.42) | CNR2BRD4PKMJAK2JAK1 | |
| SCHEMBL3700281 | 0.67 | HPGD (0.42) | CNR2PKMCNR1JAK2JAK1 | |
| SCHEMBL7371984 | 0.66 | PARP10 (0.58) | PARP10PARP14LMNACA12CA1 | |
| SCHEMBL3076585 | 0.65 | TSHR (0.67) | PKMHPGDLMNAL3MBTL1KMT2A | |
| SCHEMBL27622584 | 0.63 | CA12 (0.46) | PARP10CA12CA1CA2CA7 | |
| SCHEMBL12921864 | 0.63 | PHGDH (0.55) | PKMHPGDL3MBTL1L3MBTL3POLB | |
| SCHEMBL4777274 | 0.63 | GAA (0.72) | HPGDL3MBTL1L3MBTL3CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370407-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010080474-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |