Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 3/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL124373 | 0.76 | BTK (0.66) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL2464537 | 0.67 | CNR2 (0.42) | HPGDCNR1JAK2JAK1TYK2 | |
| SCHEMBL3227656 | 0.67 | MEN1 (0.63) | HPGDPKMMEN1KMT2A | |
| SCHEMBL30577960 | 0.65 | L3MBTL1 (0.64) | HPGDPKMMEN1KMT2A | |
| SCHEMBL1199986 | 0.65 | L3MBTL1 (0.64) | HPGDPKMMEN1KMT2A | |
| SCHEMBL367332 | 0.65 | HPGD (0.50) | HPGDMYCCNR1JAK2JAK1 | |
| SCHEMBL2467176 | 0.65 | PKM (0.41) | HPGDCNR1JAK2JAK1TYK2 | |
| SCHEMBL10720509 | 0.65 | L3MBTL1 (0.71) | HPGDPKMMEN1KMT2A | |
| SCHEMBL28133023 | 0.65 | HRH3 (0.55) | HPGDMYCCNR1JAK2JAK1 | |
| SCHEMBL365228 | 0.64 | HPGD (0.47) | HPGDCNR1JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391602-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010080481-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |