Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 7/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2464537 | 0.89 | CNR2 (0.42) | PKMCNR2BRD4JAK2CNR1 | |
| SCHEMBL2471273 | 0.83 | CNR2 (0.45) | CNR2BRD4JAK2 | |
| SCHEMBL12921864 | 0.77 | PHGDH (0.55) | PKMHPGDPOLBDNMT1PTPN7 | |
| SCHEMBL10268925 | 0.76 | L3MBTL1 (0.52) | PKMHPGDKMT2AL3MBTL1 | |
| SCHEMBL141323 | 0.74 | JAK2 (0.65) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL27833908 | 0.71 | BRD4 (0.51) | BRD4JAK2JAK1TYK2JAK3 | |
| SCHEMBL2472271 | 0.71 | GRM2 (0.42) | PKMCNR2BRD4JAK2JAK1 | |
| SCHEMBL26962479 | 0.67 | TSHR (0.56) | HPGDKMT2A | |
| SCHEMBL30563596 | 0.67 | TSHR (0.56) | HPGDKMT2A | |
| SCHEMBL22324800 | 0.66 | L3MBTL3 (0.59) | HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370407-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010080474-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |