Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 11/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2467176 | 0.71 | PKM (0.41) | GRM2JAK2BRD4PKMCNR2 | |
| SCHEMBL2464537 | 0.71 | CNR2 (0.42) | JAK2BRD4PKMCNR2JAK1 | |
| SCHEMBL2471273 | 0.67 | CNR2 (0.45) | JAK2BRD4CNR2BTK | |
| SCHEMBL3700281 | 0.63 | HPGD (0.42) | JAK2PKMCNR2JAK1TYK2 | |
| SCHEMBL10720943 | 0.60 | PHGDH (0.81) | PKMKDM4E | |
| SCHEMBL14933150 | 0.60 | GRM2 (1.00) | GRM2 | |
| SCHEMBL2999369 | 0.60 | PHGDH (0.69) | PKMKDM4E | |
| SCHEMBL8172365 | 0.59 | EPHX2 (0.71) | KDM4ENPC1RAB9A | |
| SCHEMBL546571 | 0.59 | PKM (0.62) | PKMKDM4E | |
| SCHEMBL365228 | 0.59 | HPGD (0.47) | GRM2JAK2PKMCNR2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370407-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010080474-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |