Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2464537 | 0.87 | CNR2 (0.42) | CNR2JAK2LMNABRD4 | |
| SCHEMBL2467176 | 0.83 | PKM (0.41) | CNR2JAK2BRD4 | |
| SCHEMBL140627 | 0.76 | JAK2 (0.61) | JAK2BTKBRD4 | |
| SCHEMBL6132207 | 0.71 | GPR119 (0.67) | GPR119PDE4BP2RY14NAMPT | |
| SCHEMBL407152 | 0.70 | GABRG2 (0.47) | GPR119PDE4BNAMPT | |
| SCHEMBL22438773 | 0.70 | TLR9 (0.46) | JAK2GPR119PDE4BP2RY14NAMPT | |
| SCHEMBL31198802 | 0.70 | ABL1 (0.53) | GPR119ABL1RIN1NAMPT | |
| SCHEMBL31111738 | 0.69 | NAMPT (0.56) | GPR119PDE4BP2RY14ABL1RIN1 | |
| SCHEMBL229512 | 0.69 | NAMPT (0.58) | GPR119PDE4BP2RY14ABL1RIN1 | |
| SCHEMBL14441102 | 0.68 | NR1H2 (0.55) | GPR119LMNAPDE4BABL1RIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370407-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010080474-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |