Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12333837 | 0.86 | RECQL (0.44) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL24249397 | 0.85 | HSD11B1 (0.46) | KMT2AMEN1GAAPOLBHSD11B1 | |
| Toluene SCHEMBL2464816 | 0.82 | KMT2A (0.43) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL2462081 | 0.81 | KDM4E (0.51) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL2463018 | 0.81 | KDM4E (0.51) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL19862764 | 0.79 | KMT2A (0.41) | KMT2AMEN1NPC1RAB9AKDM4E | |
| SCHEMBL29658280 | 0.75 | DRD2 (0.56) | KMT2AMEN1KDM4EGAADRD2 | |
| Hydrochloric Acid SCHEMBL29461349 | 0.74 | DRD2 (0.55) | KMT2AMEN1KDM4EGAADRD2 | |
| Hydrochloric Acid SCHEMBL29461356 | 0.74 | DRD2 (0.55) | KMT2AMEN1KDM4EGAADRD2 | |
| SCHEMBL7516057 | 0.69 | HSD11B1 (0.48) | KMT2AMEN1GAAPOLBHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044649-A1 | INFLUENZA A 2009 PANDEMIC H1N1 POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE | EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL (DE) | 2018-02-15 | — | — | US | claimed |
| US-20160053241-A1 | INFLUENZA A 2009 PANDEMIC H1N1 POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2016-02-25 | — | — | US | claimed |
| US-20130023565-A1 | INFLUENZA A 2009 PANDEMIC H1N1 POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2013-01-24 | — | — | US | claimed |
| EP-2547696-A2 | FRAGMENTS OF THE PA SUBUNIT OF RNA DEPENDENT RNA POLYMERASE FROM PANDEMIC INFLUENZA VIRUS A 2009 H1N1, AND THEIR USE | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2013-01-23 | — | — | EP | claimed |
| WO-2011113579-A2 | INFLUENZA A 2009 PANDEMIC H1N1 POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2011-09-22 | — | — | WO | claimed |
| EP-2547696-B1 | FRAGMENTS OF THE PA SUBUNIT OF RNA DEPENDENT RNA POLYMERASE FROM PANDEMIC INFLUENZA VIRUS A 2009 H1N1, AND THEIR USE | EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL (DE) | 2018-05-23 | — | — | EP | disclosed |
| US-20180044649-A1 | INFLUENZA A 2009 PANDEMIC H1N1 POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE | EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL (DE) | 2018-02-15 | — | — | US | disclosed |
| US-9783794-B2 | Influenza A 2009 pandemic H1N1 polypeptide fragments comprising endonuclease activity and their use | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2017-10-10 | — | — | US | disclosed |
| US-20160053241-A1 | INFLUENZA A 2009 PANDEMIC H1N1 POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2016-02-25 | — | — | US | disclosed |
| US-9181307-B2 | Influenza A 2009 pandemic H1N1 polypeptide fragments comprising endonuclease activity and their use | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2015-11-10 | — | — | US | disclosed |
| US-20130023565-A1 | INFLUENZA A 2009 PANDEMIC H1N1 POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE | EUROPEAN MOLECULAR BIOLOGY LABORATORY (DE) | 2013-01-24 | — | — | US | disclosed |
| EP-2547696-A2 | FRAGMENTS OF THE PA SUBUNIT OF RNA DEPENDENT RNA POLYMERASE FROM PANDEMIC INFLUENZA VIRUS A 2009 H1N1, AND THEIR USE | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011113579-A2 | INFLUENZA A 2009 PANDEMIC H1N1 POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE | EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL) (DE) | 2011-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130023565-A1 | INFLUENZA A 2009 PANDEMIC H1N1 POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE | RNASE1, RNASEH1, MME | KMT2A 1535/4885MEN1 1663/4885NPC1 2894/4885 |
| US-20160053241-A1 | INFLUENZA A 2009 PANDEMIC H1N1 POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE | RNASE1, ACE, RNASEH1 | KMT2A 1911/4885MEN1 3792/4885NPC1 2804/4885 |
| US-20180044649-A1 | INFLUENZA A 2009 PANDEMIC H1N1 POLYPEPTIDE FRAGMENTS COMPRISING ENDONUCLEASE ACTIVITY AND THEIR USE | RNASE1, ACE, RNASEH1 | KMT2A 1911/4885MEN1 3792/4885NPC1 2804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.