Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24249397 | 0.84 | HSD11B1 (0.46) | HSD11B1KMT2APKMNR3C1ALDH1A1 | |
| SCHEMBL8877293 | 0.81 | CYP2D6 (0.53) | KMT2AALDH1A1CYP3A4USP2CYP1A2 | |
| Hydrochloric Acid SCHEMBL8876539 | 0.81 | KDM4E (0.51) | KMT2APKMALDH1A1CYP3A4TSHR | |
| SCHEMBL8877209 | 0.76 | CYP2D6 (0.57) | HSD11B1KMT2APKMALDH1A1USP2 | |
| Hydrochloric Acid SCHEMBL8877767 | 0.74 | SIGMAR1 (0.51) | KMT2AALDH1A1SMN1; SMN2MEN1LMNA | |
| SCHEMBL2701428 | 0.74 | KMT2A (0.55) | HSD11B1KMT2APKMNR3C1ALDH1A1 | |
| SCHEMBL12333837 | 0.71 | RECQL (0.44) | KMT2AALDH1A1TSHRMEN1POLB | |
| Toluene SCHEMBL2464816 | 0.70 | KMT2A (0.43) | KMT2AALDH1A1MEN1POLBGAA | |
| SCHEMBL2464539 | 0.69 | KMT2A (0.40) | HSD11B1KMT2AMEN1POLBGAA | |
| Hydrochloric Acid SCHEMBL8875080 | 0.68 | OPRM1 (0.53) | LMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0833945-B1 | DNA POLYMERASE EXTENSION ASSAY | MERCK & CO INC (US) | 2002-01-30 | — | — | EP | disclosed |
| EP-0832292-B1 | DNA POLYMERASE EXTENSION ASSAY FOR INFLUENZA VIRUS ENDONUCLEASE | MERCK & CO INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-6100028-A | DETECTING SITE-SPECIFIC RIBOZYME ACTIVITY IN SAMPLE BY MIXING SUBSTRATE, SAMPLE AND INHIBITOR TO GENERATE RNA PRODUCT, HYBRIDIZING TO DNA, ADDING RADIOLABELED NUCLEOTIDE, ADDING DNA POLYMERASE, FILTERING TO RETAIN POLYMERASE PRODUCT, MEASURING | MERCK & CO., INC. (US) | 2000-08-08 | — | — | US | disclosed |
| EP-0832292-A4 | DNA POLYMERASE EXTENSION ASSAY FOR INFLUENZA VIRUS ENDONUCLEASE | MERCK & CO INC (US) | 1999-05-26 | — | — | EP | disclosed |
| EP-0833945-A4 | DNA POLYMERASE EXTENSION ASSAY | MERCK & CO INC (US) | 1999-05-19 | — | — | EP | disclosed |
| EP-0833945-A1 | DNA POLYMERASE EXTENSION ASSAY | Merck & Co., Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| EP-0832292-A1 | DNA POLYMERASE EXTENSION ASSAY FOR INFLUENZA VIRUS ENDONUCLEASE | Merck & Co., Inc. (US) | 1998-04-01 | — | — | EP | disclosed |
| US-5660989-A | DNA polymerase extension assay for influenza virus endonuclease | MERCK & CO., INC. (US) | 1997-08-26 | — | — | US | disclosed |
| WO-1996040994-A1 | DNA POLYMERASE EXTENSION ASSAY | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1996040993-A1 | DNA POLYMERASE EXTENSION ASSAY FOR INFLUENZA VIRUS ENDONUCLEASE | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | disclosed |