Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.34 |
| ▸ | CD44 | P16070 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2467191 | 0.86 | ALDH1A1 (0.36) | ALDH1A1IMPDH2TSHR | |
| SCHEMBL14992608 | 0.78 | IMPDH2 (0.32) | ALDH1A1IMPDH2TSHR | |
| SCHEMBL2464673 | 0.78 | IMPDH2 (0.31) | IMPDH2 | |
| SCHEMBL2464817 | 0.74 | P2RX7 (0.33) | ALDH1A1TSHR | |
| SCHEMBL17182454 | 0.73 | CYP3A4 (0.42) | CYP3A4ALDH1A1THRBCD44TSHR | |
| SCHEMBL525350 | 0.71 | CYP3A4 (0.65) | CYP3A4ALDH1A1THRBCD44TSHR | |
| SCHEMBL23507137 | 0.69 | P2RX7 (0.40) | ALDH1A1 | |
| SCHEMBL6155985 | 0.69 | CD44 (0.35) | CYP3A4ALDH1A1CD44TSHR | |
| SCHEMBL9566566 | 0.69 | ALDH1A1 (0.46) | CYP3A4ALDH1A1THRBTSHR | |
| SCHEMBL1124861 | 0.69 | HRH3 (0.36) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2785714-A1 | IMPROVED MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | Taivex Therapeutics Corporation (TW) | 2014-10-08 | — | — | EP | disclosed |
| WO-2013082324-A1 | IMPROVED MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | TAIVEX THERAPEUTICS CORPORATION (TW) | 2013-06-06 | — | — | WO | disclosed |
| EP-2547676-A2 | MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | Taivex Therapeutics Inc. (TW) | 2013-01-23 | — | — | EP | disclosed |
| WO-2011115998-A2 | MODULATORS OF HEC1 ACTIVITY AND METHODS THEREFOR | TAIVEX THERAPEUTICS INC. (CN) | 2011-09-22 | — | — | WO | disclosed |