Sugi Predict

Sugi Predict / Compounds / SCHEMBL2464580

SCHEMBL2464580

SCHEMBL2464580

COc1ccc(N2CCN(c3ccc(C(=O)c4ccccc4)cc3)CC2)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.66
▸ L3MBTL1 Q9Y468 3/20 0.66
▸ MAPT P10636 3/20 0.66
▸ TSHR P16473 2/20 0.66
▸ HSD17B10 Q99714 2/20 0.66
▸ SMN1; SMN2 Q16637 2/20 0.66
▸ LMNA P02545 2/20 0.66
▸ NPC1 O15118 2/20 0.66
▸ RAB9A P51151 2/20 0.66
▸ TP53 P04637 1/20 0.66
▸ HPGD P15428 1/20 0.66
▸ ALOX15 P16050 1/20 0.66
▸ STAT1 P42224 1/20 0.66
▸ HTR1A P08908 1/20 0.65
▸ POLB P06746 3/20 0.64
▸ MEN1 O00255 2/20 0.64
▸ KMT2A Q03164 2/20 0.64
▸ DRD2 P14416 1/20 0.61
▸ HTR2A P28223 1/20 0.61
▸ USP2 O75604 2/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9672113 0.87 MAPT (0.69) ALDH1A1L3MBTL1MAPTTSHRHSD17B10
SCHEMBL31164294 0.86 MAPT (0.68) ALDH1A1L3MBTL1MAPTTSHRHSD17B10
SCHEMBL2767534 0.85 DRD2 (0.81) ALDH1A1L3MBTL1MAPTSMN1; SMN2LMNA
SCHEMBL2023604 0.85 ALDH1A1 (0.82) ALDH1A1L3MBTL1MAPTTSHRHSD17B10
SCHEMBL50261 0.85 CES2 (0.77) ALDH1A1L3MBTL1MAPTSMN1; SMN2LMNA
SCHEMBL6618691 0.85 CES2 (0.77) ALDH1A1L3MBTL1MAPTSMN1; SMN2LMNA
Benzophenone SCHEMBL27935236 0.85 CES2 (0.77) ALDH1A1L3MBTL1MAPTSMN1; SMN2LMNA
SCHEMBL24688813 0.84 ALDH1A1 (0.56) ALDH1A1L3MBTL1MAPTLMNANPC1
SCHEMBL21788568 0.83 ADRB1 (0.76) ALDH1A1L3MBTL1MAPTTSHRHSD17B10
SCHEMBL28888786 0.83 CES2 (0.74) ALDH1A1L3MBTL1MAPTSMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105199708-B Photochromic compounds 光学转变公司 2020-10-27 — — CN disclosed
EP-2370420-B9 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-11-13 — — EP disclosed
EP-2370420-B1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-05-22 — — EP disclosed
US-20180291008-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2018-10-11 — — US disclosed
US-20180291007-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2018-10-11 — — US disclosed
US-20180291009-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2018-10-11 — — US disclosed
US-10005763-B2 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2018-06-26 — — US disclosed
US-10000472-B2 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2018-06-19 — — US disclosed
US-20160333262-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2016-11-17 — — US disclosed
US-20160332995-A1 Photochromic Comounds TRANSITIONS OPTICAL, INC. 2016-11-17 — — US disclosed
US-9405041-B2 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2016-08-02 — — US disclosed
US-20140154514-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2014-06-05 — — US disclosed
US-8705160-B2 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2014-04-22 — — US disclosed
US-20120200907-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2012-08-09 — — US disclosed
US-8211338-B2 Photochromic compounds TRANSITIONS OPTICAL, INC (US) 2012-07-03 — — US disclosed
EP-2370420-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2011-10-05 — — EP disclosed
WO-2010065393-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2010-06-10 — — WO disclosed
US-20090309076-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2009-12-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180291007-A1 Photochromic Compounds CCR4, CCR8, CBR3 ALDH1A1 1805/4885L3MBTL1 2464/4885MAPT 3431/4885
US-20160332995-A1 Photochromic Comounds CCR4, CCR3, CCR8 ALDH1A1 1767/4885L3MBTL1 2408/4885MAPT 3824/4885
US-10005763-B2 Photochromic compounds CCR4, CCR8, CBR3 ALDH1A1 1782/4885L3MBTL1 2456/4885MAPT 3402/4885
US-20180291008-A1 Photochromic Compounds CCR4, CBR3, CCR8 ALDH1A1 1817/4885L3MBTL1 2227/4885MAPT 3410/4885
US-20160333262-A1 Photochromic Compounds CCR4, CCR8, CBR3 ALDH1A1 1782/4885L3MBTL1 2456/4885MAPT 3402/4885
US-20180291009-A1 Photochromic Compounds CCR4, CCR8, CBR3 ALDH1A1 1831/4885L3MBTL1 2454/4885MAPT 3424/4885
US-10000472-B2 Photochromic compounds CCR4, CCR8, CBR3 ALDH1A1 1782/4885L3MBTL1 2456/4885MAPT 3402/4885
US-20120200907-A1 PHOTOCHROMIC COMPOUNDS CCR4, CCR8, CBR3 ALDH1A1 1771/4885L3MBTL1 2421/4885MAPT 3507/4885
US-20090309076-A1 PHOTOCHROMIC COMPOUNDS CCR4, CCR8, CBR3 ALDH1A1 1782/4885L3MBTL1 2456/4885MAPT 3402/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.