SCHEMBL2464675

SCHEMBL2464675

Cc1ccc(-c2cc(N)c(Cl)c(OC(=O)O)n2)cc1C=S

nearest known ligand 0.34

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMO O15229 4/20 0.34
DHODH Q02127 1/20 0.33
IL36G Q9NZH8 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
KDM4E B2RXH2 1/20 0.32
MAPT P10636 2/20 0.31
EPRS1 P07814 1/20 0.31
PTGES O14684 1/20 0.31
ALDH1A1 P00352 1/20 0.31
ALOX5 P09917 1/20 0.31
CYP2C9 P11712 1/20 0.31
HPGD P15428 1/20 0.31
CASP7 P55210 1/20 0.31
HIF1A Q16665 1/20 0.31
HSD17B10 Q99714 1/20 0.31
PLA2G2A P14555 1/20 0.31
ADORA3 P0DMS8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2470067 0.87 ALPL (0.40) KMOIL36GMEN1KMT2AKDM4E
SCHEMBL2466299 0.86 KMO (0.47) KMOIL36GKDM4EMAPT
SCHEMBL2464804 0.84 CTRC (0.33) MEN1KMT2AKDM4EMAPTEPRS1
SCHEMBL2463132 0.83 ABL1 (0.42) KMOMAPT
SCHEMBL2466248 0.83 MAPT (0.44) DHODHMEN1KMT2AKDM4EMAPT
SCHEMBL3328551 0.82 KMO (0.38) KMODHODHMAPTPTGESALDH1A1
SCHEMBL2466313 0.81 MAPT (0.43) KMOMEN1KMT2AKDM4EMAPT
SCHEMBL2468160 0.80 CTRC (0.46) KMOMEN1KMT2AKDM4EMAPT
SCHEMBL2465141 0.79 KMO (0.48) KMODHODHMEN1KMT2AKDM4E
SCHEMBL2470000 0.79 ACHE (0.45) MEN1KMT2AKDM4EMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2369929-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
WO-2010060581-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed