Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 7/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 7/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 7/20 | 0.71 |
| ▸ | HTR1D | P28221 | 5/20 | 0.71 |
| ▸ | HTR1B | P28222 | 4/20 | 0.71 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.71 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.71 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.71 |
| ▸ | TSHR | P16473 | 2/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | BLM | P54132 | 3/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.66 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11761437 | 0.87 | ADRA2C (0.71) | ADRA2AADRA2BADRA2CHTR1DHTR1B | |
| SCHEMBL11180812 | 0.86 | ADRA2A (0.76) | ADRA2AADRA2BADRA2CHTR1DHTR1B | |
| Pi-Clonidine SCHEMBL563884 | 0.83 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CHTR1DHTR1B | |
| SCHEMBL10414088 | 0.83 | ADRA2A (0.71) | ADRA2AADRA2BADRA2CHTR1DHTR1B | |
| Apraclonidine SCHEMBL34128 | 0.83 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CHTR1DHTR1B | |
| SCHEMBL11187565 | 0.83 | HTR1D (0.76) | ADRA2AADRA2BADRA2CHTR1DHTR1B | |
| Apraclonidine SCHEMBL1002875 | 0.82 | BLM (1.00) | ADRA2AADRA2BADRA2CHTR1DHTR1B | |
| Pi-Clonidine SCHEMBL5274141 | 0.82 | LMNA (1.00) | ADRA2AADRA2BADRA2CHTR1DHTR1B | |
| Bromide SCHEMBL11608848 | 0.82 | ADRA2A (0.69) | ADRA2AADRA2BADRA2CHTR1DHTR1B | |
| Apraclonidine SCHEMBL1649431 | 0.82 | ADRA2A (0.97) | ADRA2AADRA2BADRA2CHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022221071-A1 | ALPHA2 ADRENERGIC AGONIST CODRUGS CONJUGATED WITH MUSCARINIC AGONIST DRUGS | ADS THERAPEUTICS LLC (US) | 2022-10-20 | — | — | WO | disclosed |