Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31441808 | 0.82 | MMP2 (0.41) | PKMALDH1A1USP2 | |
| SCHEMBL24669805 | 0.81 | ALDH1A1 (0.35) | TP53ALDH1A1ACHESMN1; SMN2 | |
| SCHEMBL24669423 | 0.78 | MEN1 (0.43) | ALDH1A1USP2SMN1; SMN2 | |
| SCHEMBL24669646 | 0.78 | KMT2A (0.42) | — | |
| SCHEMBL31441830 | 0.77 | USP2 (0.39) | PKMALDH1A1ACHEUSP2SMN1; SMN2 | |
| SCHEMBL24669803 | 0.75 | RAB9A (0.49) | TP53ALDH1A1SMN1; SMN2 | |
| SCHEMBL31441901 | 0.74 | POLB (0.55) | ALDH1A1USP2SMN1; SMN2 | |
| SCHEMBL31441940 | 0.74 | L3MBTL1 (0.34) | PKMALDH1A1ACHESMN1; SMN2GBA1 | |
| SCHEMBL31442088 | 0.74 | ACHE (0.51) | PKMALDH1A1ACHESMN1; SMN2 | |
| SCHEMBL24669671 | 0.73 | NR1H2 (0.39) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |