Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 2/20 | 0.59 |
| ▸ | UBE2N | P61088 | 1/20 | 0.59 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24670085 | 0.88 | RAD52 (0.63) | RAD52UBE2NIDO1TDP1MAPT | |
| SCHEMBL24670057 | 0.79 | RAD52 (0.52) | RAD52UBE2NTDP1MAPTPKM | |
| SCHEMBL20054433 | 0.75 | AAK1 (0.52) | RAD52UBE2NIDO1TDP1MAPT | |
| SCHEMBL15426717 | 0.74 | RAD52 (0.50) | RAD52UBE2NIDO1TDP1MAPT | |
| SCHEMBL29409142 | 0.73 | TDP1 (0.70) | RAD52UBE2NIDO1TDP1MAPT | |
| SCHEMBL4354084 | 0.73 | TDP1 (0.70) | RAD52UBE2NIDO1TDP1MAPT | |
| SCHEMBL38661663 | 0.73 | IDO1 (0.76) | RAD52UBE2NIDO1TDP1MAPT | |
| SCHEMBL19377986 | 0.73 | HDAC3 (0.52) | RAD52UBE2NIDO1TDP1MAPT | |
| SCHEMBL4704614 | 0.73 | HTR1A (0.59) | MAPTKMT2AMEN1KDM4ERAB9A | |
| Hydrochloric Acid SCHEMBL23705615 | 0.72 | HDAC3 (0.51) | RAD52UBE2NIDO1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |