Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | RPS6KA5 | O75582 | 6/20 | 0.40 |
| ▸ | RPS6KA4 | O75676 | 3/20 | 0.40 |
| ▸ | MET | P08581 | 5/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2245552 | 0.79 | L3MBTL1 (0.52) | HTR6METRAPGEF4 | |
| SCHEMBL17194137 | 0.74 | MET (0.64) | PIK3C3HTR6RPS6KA5METRAPGEF4 | |
| SCHEMBL31428856 | 0.74 | MET (0.64) | PIK3C3HTR6RPS6KA5METRAPGEF4 | |
| SCHEMBL16926663 | 0.73 | PIK3C3 (0.50) | PIK3C3HTR6METRAPGEF4 | |
| SCHEMBL24668966 | 0.72 | ALDH3A1 (0.39) | PIK3C3HTR6RAPGEF4 | |
| SCHEMBL24670230 | 0.72 | HTR6 (0.41) | HTR6RAPGEF4 | |
| SCHEMBL256382 | 0.72 | RPS6KA5 (0.45) | RPS6KA5RPS6KA4EGFR | |
| SCHEMBL24668538 | 0.70 | HDAC6 (0.38) | — | |
| SCHEMBL24670233 | 0.70 | HTR6 (0.60) | PIK3C3HTR6RAPGEF4 | |
| SCHEMBL5738350 | 0.70 | RPS6KA5 (0.46) | RPS6KA5RPS6KA4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187693-A1 | COVALENT CDK2-BINDING COMPOUNDS FOR THERAPEUTIC PURPOSES | UMBRA THERAPEUTICS INC. (US) | 2022-09-09 | — | — | WO | disclosed |