Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19762359 | 0.90 | KDM4E (0.46) | MEN1KMT2ANR1H3ALDH1A1KDM4E | |
| SCHEMBL10022401 | 0.86 | POLB (0.54) | MEN1KMT2ANR1H3ALDH1A1KDM4E | |
| SCHEMBL10022390 | 0.85 | KDM4E (0.63) | MEN1KMT2ANR1H3ALDH1A1KDM4E | |
| SCHEMBL2835024 | 0.80 | NR1H3 (0.58) | MEN1KMT2ANR1H3ALDH1A1KDM4E | |
| SCHEMBL18954622 | 0.80 | PARK7 (0.48) | MEN1KMT2ANR1H3ALDH1A1LMNA | |
| SCHEMBL25144719 | 0.79 | MAPT (0.46) | MEN1KMT2AALDH1A1KDM4ERAB9A | |
| SCHEMBL19762356 | 0.79 | RORA (0.45) | MEN1KMT2ANR1H3ALDH1A1KDM4E | |
| SCHEMBL25144724 | 0.79 | SMN1; SMN2 (0.42) | MEN1KMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL25144720 | 0.78 | ALDH1A1 (0.51) | MEN1KMT2AALDH1A1KDM4ERAB9A | |
| SCHEMBL15046557 | 0.77 | CHRM2 (0.60) | ALDH1A1KDM4ENPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |