Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26948627 | 0.79 | HRH3 (0.34) | HRH3KCNH2 | |
| SCHEMBL24501935 | 0.73 | EPHX2 (0.43) | HRH3KCNH2ALDH1A1CYP2D6EPHX2 | |
| SCHEMBL22520624 | 0.72 | CACNA2D1 (0.43) | HRH3KCNH2ALDH1A1CYP2D6EPHX2 | |
| SCHEMBL24671522 | 0.70 | HSD11B1 (0.43) | HRH3KCNH2ALDH1A1CYP2D6EPHX2 | |
| SCHEMBL10154480 | 0.70 | HRH3 (0.46) | HRH3KCNH2ALDH1A1CHRM1CYP2D6 | |
| SCHEMBL25075012 | 0.68 | HSD11B1 (0.42) | HRH3KCNH2ALDH1A1CHRM1CYP2D6 | |
| SCHEMBL16775761 | 0.68 | CHRM1 (0.47) | HRH3KCNH2ALDH1A1CHRM1CYP2D6 | |
| SCHEMBL25443839 | 0.67 | HRH3 (0.48) | HRH3KCNH2ALDH1A1CYP2D6KDM4E | |
| SCHEMBL26949618 | 0.66 | HRH3 (0.36) | HRH3KCNH2 | |
| SCHEMBL12820238 | 0.66 | ALDH1A1 (0.50) | ALDH1A1CNR1EPHX2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |