Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 4/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30066376 | 1.00 | HSD11B1 (0.39) | HSD11B1MGLLPDE4BHTR2ADRD2 | |
| SCHEMBL30816873 | 0.92 | SOS1 (0.41) | SOS1 | |
| SCHEMBL30009715 | 0.89 | MGLL (0.38) | HSD11B1MGLL | |
| SCHEMBL23121762 | 0.89 | MGLL (0.38) | HSD11B1MGLL | |
| SCHEMBL24670709 | 0.88 | PDE4B (0.46) | HSD11B1MGLLPDE4BFAAH | |
| SCHEMBL30066197 | 0.88 | PDE4B (0.46) | HSD11B1MGLLPDE4BFAAH | |
| Hydrochloric Acid SCHEMBL23121946 | 0.88 | MGLL (0.37) | HSD11B1MGLL | |
| Hydrochloric Acid SCHEMBL30009282 | 0.88 | MGLL (0.37) | HSD11B1MGLL | |
| SCHEMBL31447662 | 0.86 | SOS1 (0.44) | HSD11B1SOS1 | |
| SCHEMBL31447872 | 0.83 | DDB1 (0.45) | DRD2SIGMAR1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |