Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | PPID | Q08752 | 1/20 | 0.44 |
| ▸ | GLS | O94925 | 2/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19387601 | 0.84 | KDM4E (0.45) | PPARAPPARGROCK2 | |
| SCHEMBL7475639 | 0.82 | SMN1; SMN2 (0.56) | PPARAPPARGCYP3A4CYP2C9SMN1; SMN2 | |
| SCHEMBL18705329 | 0.81 | ALDH1A1 (0.46) | PPARAPPARGSMN1; SMN2 | |
| SCHEMBL1669761 | 0.81 | NAMPT (0.41) | PPARAPPARGCYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL10799448 | 0.81 | PPARA (0.55) | PPARAPPARGSMN1; SMN2 | |
| SCHEMBL14431530 | 0.81 | PPARA (0.57) | PPARAPPARG | |
| SCHEMBL24674846 | 0.81 | ROCK2 (0.47) | BRD4GLSROCK2CYP3A4CYP2D6 | |
| SCHEMBL3418637 | 0.80 | ALDH1A1 (0.62) | MMP13SMN1; SMN2 | |
| SCHEMBL24674847 | 0.80 | GLS (0.46) | BRD4GLSMMP13SMN1; SMN2 | |
| SCHEMBL23461821 | 0.80 | ROCK2 (0.49) | BRD4GLSROCK2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |