Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 3/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24674846 | 0.84 | ROCK2 (0.47) | GLSBRD4SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL694491 | 0.83 | GLS (0.56) | GLSBRD4KDM4ACREBBPL3MBTL1 | |
| SCHEMBL3418637 | 0.83 | ALDH1A1 (0.62) | SMN1; SMN2ALDH1A1HTTMMP13L3MBTL1 | |
| SCHEMBL20946412 | 0.82 | MAPT (0.47) | GLSBRD4ALDH1A1HTTL3MBTL1 | |
| SCHEMBL23461821 | 0.82 | ROCK2 (0.49) | GLSBRD4SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL29996911 | 0.82 | ROCK2 (0.49) | GLSBRD4SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL28246608 | 0.81 | CYP3A4 (0.49) | GLSBRD4SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL19553568 | 0.81 | KCNA5 (0.45) | GLSBRD4L3MBTL1 | |
| SCHEMBL24674845 | 0.80 | PPARA (0.56) | GLSBRD4SMN1; SMN2MMP13 | |
| SCHEMBL24675183 | 0.80 | ROCK2 (0.49) | GLSBRD4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |