Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24677759 | 0.89 | MRGPRX4 (0.47) | MRGPRX4LMNATSHRALDH1A1CYP1A2 | |
| SCHEMBL24677760 | 0.88 | MRGPRX4 (0.46) | MRGPRX4LMNATSHRALDH1A1CYP1A2 | |
| SCHEMBL30447357 | 0.88 | MRGPRX4 (0.46) | MRGPRX4LMNATSHRALDH1A1CYP1A2 | |
| SCHEMBL25950565 | 0.87 | LMNA (0.42) | MRGPRX4LMNATSHRALDH1A1CYP1A2 | |
| SCHEMBL25950573 | 0.81 | ALDH1A1 (0.42) | MRGPRX4LMNAALDH1A1CYP1A2HSP90AA1 | |
| SCHEMBL24677801 | 0.79 | HTT (0.50) | MRGPRX4ALDH1A1MAPTCYP2C9SMN1; SMN2 | |
| SCHEMBL30558899 | 0.79 | HTT (0.50) | MRGPRX4ALDH1A1MAPTCYP2C9SMN1; SMN2 | |
| SCHEMBL14691336 | 0.76 | ALDH1A1 (0.50) | LMNAALDH1A1CYP1A2HSP90AA1MAPT | |
| SCHEMBL29831705 | 0.76 | MRGPRX4 (0.51) | MRGPRX4ALDH1A1TP53HTT | |
| SCHEMBL24677896 | 0.76 | MRGPRX4 (0.51) | MRGPRX4ALDH1A1TP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220306681-A1 | CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | ELI LILLY AND COMPANY | 2022-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220306681-A1 | CARBOXY SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | NR3C1, MC2R, NR3C2 | MRGPRX4 28/4885LMNA 4331/4885TSHR 174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.