SCHEMBL2467819

SCHEMBL2467819

COc1ccc(-c2cc(N)c(Cl)c(C(=O)O)n2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.52
MCL1 Q07820 2/20 0.48
DYRK1A Q13627 1/20 0.48
PRKAG1 P54619 2/20 0.47
PRKAA1 Q13131 2/20 0.47
PRKAB1 Q9Y478 2/20 0.47
PLA2G2A P14555 2/20 0.47
PRKAB2 O43741 1/20 0.47
PRKAA2 P54646 1/20 0.47
PRKAG3 Q9UGI9 1/20 0.47
PRKAG2 Q9UGJ0 1/20 0.47
CASP1 P29466 1/20 0.47
ALPL P05186 1/20 0.47
CA9 Q16790 1/20 0.47
CHEK1 O14757 1/20 0.47
PRKDC P78527 1/20 0.46
ATR Q13535 1/20 0.46
TP53 P04637 1/20 0.45
MAPT P10636 1/20 0.45
THRB P10828 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2467009 0.88 KDM4E (0.52) KDM4EDYRK1APLA2G2ACASP1ALPL
SCHEMBL27504255 0.86 PIN1 (0.51) DYRK1APRKAG1PRKAA1PRKAB1PRKAB2
SCHEMBL2466247 0.85 DHODH (0.49) KDM4EALPLATRTP53MAPT
SCHEMBL2468156 0.84 CTRC (0.51) KDM4EMCL1CASP1ALPLATR
SCHEMBL2468348 0.84 MAPT (0.54) KDM4ECASP1MAPTSMN1; SMN2ADORA3
SCHEMBL27837915 0.83 KMO (0.54) KDM4EDYRK1AMAPT
SCHEMBL2468412 0.83 DHODH (0.55) MAPTADORA3
SCHEMBL2469483 0.83 MKNK1 (0.46) PRKAG1PRKAA1PRKAB1ATR
SCHEMBL16075389 0.83 GRM2 (0.42) KDM4EMCL1PRKAG1PRKAA1PRKAB1
SCHEMBL3329998 0.83 CTRC (0.54) KDM4EMCL1TP53MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
US-8962523-B2 Herbicide/safener combination BAYER CROPSCIENCE AG (DE) 2015-02-24 US disclosed
US-20150051074-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2015-02-19 US disclosed
CN-102300459-A Herbicide-safener combination 2011-12-28 CN disclosed
EP-2369929-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
WO-2010060581-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
US-20100137137-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 US disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed
EP-1414814-B1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2005-02-02 EP disclosed
US-6784137-B2 SUCH AS 5,6-DICHLOROPYRIDINE-2-CARBOXYLIC ACID-N-OXIDE FOR PREEMERGENCE APPLICATION DOW AGROSCIENCES LLC 2004-08-31 US disclosed
EP-1414814-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 2004-05-06 EP disclosed
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides CORTEVA AGRISCIENCE LLC 2003-06-19 US disclosed
WO-2003011853-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2003-02-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100137137-A1 HERBICIDE/SAFENER COMBINATION DDT, CYP2W1, GAP43 KDM4E 4579/4885MCL1 1314/4885DYRK1A 752/4885
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides AADAC, DDT, AADAT KDM4E 969/4885MCL1 4369/4885DYRK1A 1100/4885
US-20150051074-A1 HERBICIDE/SAFENER COMBINATION DDT, CYP2W1, GAP43 KDM4E 4579/4885MCL1 1314/4885DYRK1A 752/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.