SCHEMBL2468348

SCHEMBL2468348

COc1ccc(-c2cc(N)c(Cl)c(C(=O)O)n2)cc1OC

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.54
MEN1 O00255 5/20 0.51
KMT2A Q03164 5/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
ADORA3 P0DMS8 2/20 0.47
DHODH Q02127 1/20 0.46
KDM4E B2RXH2 4/20 0.46
ALDH1A1 P00352 3/20 0.46
HSD17B10 Q99714 2/20 0.46
TSHR P16473 2/20 0.46
MAPK1 P28482 2/20 0.46
HPGD P15428 2/20 0.46
USP2 O75604 1/20 0.46
HTT P42858 1/20 0.46
ATM Q13315 1/20 0.46
KMO O15229 3/20 0.45
AGTR1 P30556 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
CASP1 P29466 1/20 0.44
LMNA P02545 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27837915 0.91 KMO (0.54) MAPTMEN1KMT2AL3MBTL1KDM4E
SCHEMBL2466311 0.90 MAPT (0.45) MAPTMEN1KMT2AL3MBTL1ADORA3
SCHEMBL29036877 0.89 MAPT (0.47) MAPTMEN1KMT2AL3MBTL1KDM4E
SCHEMBL28743640 0.89 MAPT (0.44) MAPTMEN1KMT2AL3MBTL1ADORA3
SCHEMBL2468162 0.89 DHODH (0.51) MAPTMEN1KMT2AL3MBTL1ADORA3
SCHEMBL2467819 0.84 KDM4E (0.52) MAPTADORA3KDM4ESMN1; SMN2CASP1
SCHEMBL2468353 0.82 MEN1 (0.52) MAPTMEN1KMT2AL3MBTL1ADORA3
SCHEMBL2469483 0.81 MKNK1 (0.46) MEN1KMT2AUSP2
SCHEMBL27504255 0.81 PIN1 (0.51) MAPTMEN1KMT2AADORA3ALDH1A1
SCHEMBL2470066 0.80 ALPL (0.46) MAPTKDM4EALDH1A1HPGDKMO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2939540-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
EP-2939541-A1 HERBICIDE SAFENER COMBINATION Bayer Intellectual Property GmbH (DE) 2015-11-04 EP disclosed
US-8962523-B2 Herbicide/safener combination BAYER CROPSCIENCE AG (DE) 2015-02-24 US disclosed
US-20150051074-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2015-02-19 US disclosed
EP-2369929-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
WO-2010060581-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
US-20100137137-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 US disclosed
EP-2191719-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-06-02 EP disclosed
EP-1414814-B1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2005-02-02 EP disclosed
US-6784137-B2 SUCH AS 5,6-DICHLOROPYRIDINE-2-CARBOXYLIC ACID-N-OXIDE FOR PREEMERGENCE APPLICATION DOW AGROSCIENCES LLC 2004-08-31 US disclosed
EP-1414814-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES Dow Agrosciences LLC (US) 2004-05-06 EP disclosed
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides CORTEVA AGRISCIENCE LLC 2003-06-19 US disclosed
WO-2003011853-A1 6-ARYL-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2003-02-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100137137-A1 HERBICIDE/SAFENER COMBINATION DDT, CYP2W1, GAP43 MAPT 4056/4885MEN1 3489/4885KMT2A 1867/4885
US-20030114311-A1 6-Aryl-4-aminopicolinates and their use as herbicides AADAC, DDT, AADAT MAPT 526/4885MEN1 4459/4885KMT2A 344/4885
US-20150051074-A1 HERBICIDE/SAFENER COMBINATION DDT, CYP2W1, GAP43 MAPT 4056/4885MEN1 3489/4885KMT2A 1867/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.