SCHEMBL2469159

SCHEMBL2469159

Nc1c(Cl)c(C(=O)O)nc(C2CC2)c1Cl

nearest known ligand 0.58

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.58
FABP4 P15090 1/20 0.35
FABP5 Q01469 1/20 0.35
HCAR2 Q8TDS4 2/20 0.33
ACHE P22303 1/20 0.33
MAPT P10636 2/20 0.31
ATM Q13315 2/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
LMNA P02545 1/20 0.31
GAA P10253 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2469816 0.85 TDP1 (0.49) TDP1FABP4FABP5HCAR2ACHE
SCHEMBL2463927 0.81 NPSR1 (0.40) TDP1MAPTATML3MBTL1LMNA
SCHEMBL15791914 0.80 TDP1 (0.46) TDP1HCAR2
SCHEMBL2469161 0.76 TDP1 (0.34) TDP1
SCHEMBL20955555 0.74 TDP1 (0.47) TDP1LMNA
Picloram SCHEMBL8467014 0.74 TDP1 (1.00) TDP1HCAR2MAPTATML3MBTL1
Picloram SCHEMBL29388079 0.74 TDP1 (1.00) TDP1HCAR2MAPTATML3MBTL1
Picloram SCHEMBL13299 0.74 TDP1 (1.00) TDP1HCAR2MAPTATML3MBTL1
SCHEMBL16196390 0.73 FABP4 (0.38) TDP1FABP4FABP5HCAR2
SCHEMBL287902 0.72 PDE10A (0.46) TDP1HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2369927-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP claimed
US-20100137136-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 US claimed
WO-2010060579-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO claimed
WO-2006062979-A1 HERBICIDAL 6-CYCLOPROPYL-SUBSTITUTE 4-AMINOPICOLINIC ACID DERIVATIVES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2006-06-15 WO claimed
EP-2369927-A2 HERBICIDE-SAFENER COMBINATION Bayer CropScience AG (DE) 2011-10-05 EP disclosed
EP-2210492-A1 Herbicide safener combination Bayer CropScience AG (DE) 2010-07-28 EP disclosed
US-20100137136-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 US disclosed
WO-2010060579-A2 HERBICIDE-SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 WO disclosed
WO-2006062979-A1 HERBICIDAL 6-CYCLOPROPYL-SUBSTITUTE 4-AMINOPICOLINIC ACID DERIVATIVES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2006-06-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100137136-A1 HERBICIDE/SAFENER COMBINATION DDT, GAP43, CYP2W1 TDP1 471/4885FABP4 1319/4885FABP5 1894/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.