Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18844837 | 0.83 | ENPP2 (0.55) | EPHX1ALDH1A1HTTENPP2MEN1 | |
| SCHEMBL10596369 | 0.80 | ENPP2 (0.59) | EPHX1ALDH1A1HTTENPP2MEN1 | |
| SCHEMBL20862403 | 0.77 | TAS1R3 (0.57) | EPHX1ALDH1A1HTTMEN1MAPT | |
| SCHEMBL19612835 | 0.75 | PKM (0.54) | EPHX1ALDH1A1MEN1MAPK1KMT2A | |
| SCHEMBL17672415 | 0.74 | EPHX2 (0.54) | MAPTSMN1; SMN2CNR2 | |
| SCHEMBL6375568 | 0.73 | PKM (0.66) | EPHX1ALDH1A1HTTMEN1MAPK1 | |
| SCHEMBL3693343 | 0.73 | CTRB1 (0.58) | ALDH1A1HTTCNR2 | |
| SCHEMBL12175958 | 0.72 | EPHX1 (0.57) | EPHX1ALDH1A1HTTMEN1MAPT | |
| SCHEMBL11045235 | 0.70 | TDP1 (0.42) | EPHX1ALDH1A1HTTENPP2MEN1 | |
| SCHEMBL11518363 | 0.70 | MEN1 (0.81) | EPHX1ALDH1A1HTTMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3412663-B1 | NITROGEN-CONTAINING HETEROCYCLE AND CARBOCYCLE DERIVATIVES HAVING TRKA INHIBITORY ACTIVITY | SHIONOGI & CO (JP) | 2022-09-07 | — | — | EP | disclosed |