Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | HRH2 | P25021 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24697691 | 0.87 | KDM4E (0.40) | IGF1RKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL24698922 | 0.81 | HSD17B10 (0.35) | IGF1RKDM4EALDH1A1HPGDATM | |
| SCHEMBL24698106 | 0.81 | HRH2 (0.39) | IGF1RKDM4EALDH1A1HPGDHTT | |
| SCHEMBL24698728 | 0.79 | KDM4E (0.36) | IGF1RKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL24698161 | 0.78 | CYP11B2 (0.39) | IGF1RKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL24699459 | 0.78 | GBA1 (0.39) | IGF1RKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL24698813 | 0.75 | IGF1R (0.37) | IGF1RKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL24697555 | 0.75 | PIK3CA (0.49) | IGF1RKDM4EALDH1A1HPGDHTT | |
| SCHEMBL24699440 | 0.75 | PIK3CA (0.49) | KDM4EALDH1A1HRH2HRH3 | |
| SCHEMBL24697795 | 0.74 | ALDH1A1 (0.40) | IGF1RKDM4EALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |