Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1421843 | 0.85 | MKNK1 (0.62) | HPGDSSMN1; SMN2KDM4EALOX5CYP2A6 | |
| SCHEMBL27768593 | 0.83 | NPC1 (0.59) | HPGDSSMN1; SMN2KDM4EALOX5CYP2A6 | |
| SCHEMBL12725601 | 0.81 | NPC1 (0.49) | HPGDSSMN1; SMN2KDM4ECYP2A6RAB9A | |
| SCHEMBL14343335 | 0.81 | CYP3A4 (0.63) | HPGDSSMN1; SMN2KDM4ECYP2A6RAB9A | |
| SCHEMBL29548990 | 0.81 | CYP3A4 (0.56) | HPGDSSMN1; SMN2KDM4ECYP2A6RAB9A | |
| SCHEMBL5392323 | 0.81 | CYP3A4 (0.56) | HPGDSSMN1; SMN2KDM4ECYP2A6RAB9A | |
| Hydrochloric Acid SCHEMBL1421806 | 0.80 | NPC1 (0.48) | HPGDSSMN1; SMN2KDM4ECYP2A6RAB9A | |
| SCHEMBL14343023 | 0.78 | HPGDS (0.46) | HPGDSSMN1; SMN2KDM4EALOX5CYP2A6 | |
| SCHEMBL14343021 | 0.78 | HPGDS (0.46) | HPGDSSMN1; SMN2KDM4EALOX5CYP2A6 | |
| SCHEMBL11388698 | 0.78 | ALDH1A1 (0.51) | HPGDSSMN1; SMN2CYP2A6RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220396586-A1 | THIAZOLE CARBOXAMIDE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT INC (US) | 2022-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220396586-A1 | THIAZOLE CARBOXAMIDE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | GOT2, ABAT, SDHA | HPGDS 1322/4885SMN1; SMN2 3634/4885KDM4E 2689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.