Sugi Predict

Sugi Predict / Compounds / SCHEMBL2470883

SCHEMBL2470883

SCHEMBL2470883

COc1cc2c3c(c4c(c2cc1C#N)-c1ccccc1C4(C)C)C=CC(c1ccccc1)(c1ccc(N2CCN(c4ccccc4OC)CC2)cc1)O3

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DRD2 P14416 8/20 0.39
▸ DRD4 P21917 6/20 0.39
▸ DRD3 P35462 6/20 0.39
▸ HRH2 P25021 3/20 0.35
▸ HRH1 P35367 3/20 0.35
▸ TSHR P16473 2/20 0.34
▸ ADRA1A P35348 2/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ ADRA2B P18089 1/20 0.34
▸ HTR7 P34969 2/20 0.33
▸ ALDH1A1 P00352 2/20 0.32
▸ MAPT P10636 2/20 0.32
▸ SLC6A3 Q01959 1/20 0.32
▸ KDM4E B2RXH2 1/20 0.32
▸ LMNA P02545 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ HSD17B10 Q99714 1/20 0.32
▸ TDP1 Q9NUW8 1/20 0.32
▸ L3MBTL1 Q9Y468 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20527906 0.90 DRD2 (0.36) DRD2DRD4DRD3HRH2HRH1
SCHEMBL2470994 0.89 DRD2 (0.33) DRD2DRD4DRD3HRH2HRH1
SCHEMBL2018673 0.88 DRD2 (0.32) DRD2DRD4DRD3HRH2HRH1
SCHEMBL1965737 0.88 ADRA1A (0.35) DRD2DRD4DRD3HRH2HRH1
SCHEMBL2200006 0.88 ACHE (0.35) DRD2HRH1TSHRADRA2BHTR7
SCHEMBL2023151 0.86 DRD2 (0.31) DRD2DRD4DRD3HRH2HRH1
SCHEMBL1963472 0.86 DRD2 (0.35) DRD2DRD4DRD3HRH2HRH1
SCHEMBL11995963 0.85 PIK3CA (0.35) DRD2DRD4DRD3HRH2HRH1
SCHEMBL25605060 0.85 PIK3CA (0.35) DRD2DRD4DRD3HRH2HRH1
SCHEMBL29453309 0.85 STK10 (0.35) TSHRCYP1A2CYP3A4ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2370420-B9 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-11-13 — — EP claimed
EP-2370420-B1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-05-22 — — EP claimed
US-8211338-B2 Photochromic compounds TRANSITIONS OPTICAL, INC (US) 2012-07-03 — — US claimed
EP-2370420-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2011-10-05 — — EP claimed
WO-2010065393-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2010-06-10 — — WO claimed
US-20090309076-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2009-12-17 — — US claimed
EP-2370420-B9 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-11-13 — — EP disclosed
EP-2370420-B1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-05-22 — — EP disclosed
US-20180291009-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2018-10-11 — — US disclosed
US-20180291008-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2018-10-11 — — US disclosed
US-20180291007-A1 Photochromic Compounds TRANSITIONS OPTICAL, INC. 2018-10-11 — — US disclosed
US-10005763-B2 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2018-06-26 — — US disclosed
US-10000472-B2 Photochromic compounds TRANSITIONS OPTICAL, INC. (US) 2018-06-19 — — US disclosed
EP-2652553-A1 PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS Transitions Optical, Inc. (US) 2013-10-23 — — EP disclosed
US-20120200907-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2012-08-09 — — US disclosed
US-8211338-B2 Photochromic compounds TRANSITIONS OPTICAL, INC (US) 2012-07-03 — — US disclosed
WO-2012082383-A1 PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS TRANSITIONS OPTICAL, INC. (US) 2012-06-21 — — WO disclosed
EP-2370420-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2011-10-05 — — EP disclosed
WO-2010065393-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2010-06-10 — — WO disclosed
US-20090309076-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2009-12-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180291007-A1 Photochromic Compounds CCR4, CCR8, CBR3 DRD2 180/4885DRD4 91/4885DRD3 105/4885
US-10005763-B2 Photochromic compounds CCR4, CCR8, CBR3 DRD2 172/4885DRD4 91/4885DRD3 99/4885
US-20180291008-A1 Photochromic Compounds CCR4, CBR3, CCR8 DRD2 163/4885DRD4 90/4885DRD3 104/4885
US-20180291009-A1 Photochromic Compounds CCR4, CCR8, CBR3 DRD2 182/4885DRD4 91/4885DRD3 104/4885
US-10000472-B2 Photochromic compounds CCR4, CCR8, CBR3 DRD2 172/4885DRD4 91/4885DRD3 99/4885
US-20120200907-A1 PHOTOCHROMIC COMPOUNDS CCR4, CCR8, CBR3 DRD2 166/4885DRD4 88/4885DRD3 101/4885
US-20090309076-A1 PHOTOCHROMIC COMPOUNDS CCR4, CCR8, CBR3 DRD2 172/4885DRD4 91/4885DRD3 99/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.