Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2473829 | 0.86 | DHODH (0.45) | MAPTNPC1MAPK14DHODHCACNA1F | |
| SCHEMBL2472497 | 0.82 | MAPK14 (0.49) | MAPTMAPK14L3MBTL1PTGS1PTGS2 | |
| SCHEMBL2474850 | 0.81 | NPC1 (0.46) | MAPTNPC1MAPK14DHODHGABRA5 | |
| SCHEMBL2472887 | 0.80 | PTGS1 (0.48) | MAPTNPC1MAPK14GABRA5L3MBTL1 | |
| SCHEMBL2472364 | 0.76 | GABRA5 (0.43) | MAPTNPC1MAPK14GABRA5L3MBTL1 | |
| SCHEMBL2471679 | 0.71 | PTGS2 (0.50) | MAPTMAPK14L3MBTL1PTGS1PTGS2 | |
| SCHEMBL2468902 | 0.71 | PTGS1 (0.47) | MAPTNPC1MAPK14GABRA5L3MBTL1 | |
| SCHEMBL2470836 | 0.70 | MAPK14 (0.48) | MAPTMAPK14PTGS1PTGS2POLB | |
| SCHEMBL2470928 | 0.70 | MAPK14 (0.48) | MAPTMAPK14GABRA5L3MBTL1PTGS1 | |
| SCHEMBL2470784 | 0.68 | MAPK14 (0.42) | MAPTMAPK14GABRA5L3MBTL1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968973-B1 | ARYL-ISOXAZOL-4-YL-IMIDAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-10-05 | — | — | EP | claimed |