Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | CASP1 | P29466 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8013552 | 0.81 | ALDH1A1 (0.40) | ALDH1A1TSHRCASP1MAPTKDM4E | |
| SCHEMBL15172767 | 0.79 | ALDH1A1 (0.48) | ALDH1A1TSHRCASP1MAPTKDM4E | |
| SCHEMBL1425839 | 0.77 | CYP3A4 (0.40) | ALDH1A1TSHRCASP1MAPTTDP1 | |
| SCHEMBL1201436 | 0.77 | ALDH1A1 (0.46) | ALDH1A1TSHRCASP1MAPTKDM4E | |
| SCHEMBL932188 | 0.75 | ALDH1A1 (0.39) | ALDH1A1CYP3A4ALOX15HSD17B1HSD17B2 | |
| SCHEMBL2659542 | 0.75 | TRPA1 (0.44) | ALDH1A1TSHRCASP1MAPTKDM4E | |
| SCHEMBL405898 | 0.75 | CD44 (0.44) | ALDH1A1TSHRCASP1MAPTKDM4E | |
| SCHEMBL14908341 | 0.75 | EP300 (0.41) | ALDH1A1TSHRMAPTKDM4EGAA | |
| SCHEMBL2795922 | 0.75 | ALDH1A1 (0.41) | ALDH1A1TSHRCASP1MAPTKDM4E | |
| SCHEMBL1009105 | 0.75 | ALDH1A1 (0.38) | ALDH1A1TSHRMAPTHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11518766-B2 | Tricyclic compound, preparation method therefor and use thereof | SHANGHAI JEMINCARE PHARMACEUTICALS CO., LTD. (CN) | 2022-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11518766-B2 | Tricyclic compound, preparation method therefor and use thereof | TFPI, TFPI2, F11 | ALDH1A1 3573/4885TSHR 2228/4885CASP1 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.