Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL139274 | 0.78 | L3MBTL1 (0.41) | L3MBTL1KDM4EPOLBALDH1A1CFTR | |
| SCHEMBL139273 | 0.77 | MKNK1 (0.45) | L3MBTL1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL109071 | 0.75 | CA12 (0.42) | L3MBTL1KDM4EPOLBALDH1A1HSD17B10 | |
| SCHEMBL139223 | 0.75 | MAPT (0.47) | L3MBTL1KDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL111300 | 0.75 | ALDH1A1 (0.41) | L3MBTL1DHODHKDM4EALDH1A1GAA | |
| SCHEMBL23958640 | 0.74 | LMNA (0.49) | L3MBTL1DHODHKDM4EALDH1A1HSD17B10 | |
| SCHEMBL110319 | 0.74 | MAPT (0.48) | L3MBTL1DHODHCNR1KDM4EPOLB | |
| SCHEMBL143872 | 0.73 | KDM4E (0.46) | L3MBTL1KDM4EPOLBALDH1A1CFTR | |
| SCHEMBL31264183 | 0.73 | KDM4E (0.46) | L3MBTL1KDM4EPOLBALDH1A1CFTR | |
| SCHEMBL110248 | 0.72 | KDM4E (0.42) | L3MBTL1CNR1KDM4EPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370407-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010080474-A1 | CARBAZOLE AND CARBOLINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-07-15 | — | — | WO | disclosed |