SCHEMBL24736633

SCHEMBL24736633

COC(=O)c1cc(C)cc(-c2ccc(N3CCC(NC(=O)OC(C)(C)C)CC3)cc2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CKS1B P61024 1/20 0.44
SKP1 P63208 1/20 0.44
SKP2 Q13309 1/20 0.44
GPR119 Q8TDV5 4/20 0.43
SUV39H2 Q9H5I1 3/20 0.42
KDM4D Q6B0I6 2/20 0.42
SYK P43405 1/20 0.41
CNR1 P21554 1/20 0.40
CNR2 P34972 1/20 0.40
CFTR P13569 1/20 0.39
MET P08581 1/20 0.39
NAMPT P43490 1/20 0.39
KCNA3 P22001 1/20 0.39
USP14 P54578 1/20 0.39
BTK Q06187 1/20 0.38
KDM4E B2RXH2 1/20 0.38
NPC1 O15118 1/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38
HPGD P15428 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30735885 1.00 CKS1B (0.44) CKS1BSKP1SKP2GPR119SUV39H2
SCHEMBL24736635 0.91 CKS1B (0.47) CKS1BSKP1SKP2GPR119SUV39H2
SCHEMBL5203538 0.85 ALDH1A1 (0.51) CKS1BSKP1SKP2GPR119SUV39H2
SCHEMBL3284353 0.79 KDM4D (0.44) CKS1BSKP1SKP2GPR119SUV39H2
SCHEMBL3282162 0.79 KDM4D (0.51) CKS1BSKP1SKP2GPR119SUV39H2
SCHEMBL14155926 0.79 KDM4D (0.53) CKS1BSKP1SKP2GPR119SUV39H2
SCHEMBL8603748 0.79 KDM4D (0.53) CKS1BSKP1SKP2GPR119SUV39H2
SCHEMBL30116297 0.78 GPR119 (0.47) CKS1BSKP1SKP2GPR119SUV39H2
SCHEMBL3282053 0.78 CKS1B (0.45) CKS1BSKP1SKP2SUV39H2KDM4D
SCHEMBL3281872 0.78 DRD2 (0.44) CKS1BSKP1SKP2SUV39H2KDM4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240246948-A1 BENZAMIDE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER CONTAINING SAME AS ACTIVE INGREDIENT HK INNO.N CORPORATION (KR) 2024-07-25 US disclosed
EP-4342882-A1 BENZAMIDE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER CONTAINING SAME AS ACTIVE INGREDIENT HK inno.N Corporation (KR) 2024-03-27 EP disclosed
CN-117396463-A Benzamide derivative for preventing or treating cancer, method for preparing the same, and pharmaceutical composition containing the same as active ingredient 怡诺安有限公司 2024-01-12 CN disclosed
WO-2022245061-A1 BENZAMIDE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER CONTAINING SAME AS ACTIVE INGREDIENT 에이치케이이노엔 주식회사 2022-11-24 WO disclosed
WO-2022245061-A1 BENZAMIDE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER CONTAINING SAME AS ACTIVE INGREDIENT 에이치케이이노엔 주식회사 2022-11-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240246948-A1 BENZAMIDE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CANCER CONTAINING SAME AS ACTIVE INGREDIENT EGFR, ERBB2, TP53 CKS1B 272/4885SKP1 1133/4885SKP2 1555/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.