Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.39 |
| ▸ | EEF2K | O00418 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23487421 | 0.88 | CHRM5 (0.36) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL28907793 | 0.88 | ACHE (0.40) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL28535049 | 0.88 | ADRA2C (0.45) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL28533132 | 0.84 | PIM1 (0.37) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL23323108 | 0.81 | PIM1 (0.40) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL24853469 | 0.79 | TAAR1 (0.40) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL23323167 | 0.78 | TAAR1 (0.37) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL31198346 | 0.74 | KEAP1 (0.48) | KEAP1MAPK1EEF2KCHRNA7MEN1 | |
| SCHEMBL23064483 | 0.74 | KEAP1 (0.48) | KEAP1MAPK1EEF2KCHRNA7MEN1 | |
| SCHEMBL18701462 | 0.73 | HTR2C (0.50) | KEAP1MAPK1ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| WO-2022256489-A1 | METHODS OF TREATING B-CELL MALIGNANCY USING BCL-2 INHIBITOR | BEIGENE, LTD. (KY) | 2022-12-08 | — | — | WO | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |