Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24737114 | 0.88 | KEAP1 (0.41) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL23487421 | 0.82 | CHRM5 (0.36) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL28535049 | 0.82 | ADRA2C (0.45) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL22820483 | 0.81 | CCR5 (0.40) | L3MBTL1MAPTMEN1KMT2AHSD17B10 | |
| SCHEMBL28533132 | 0.79 | PIM1 (0.37) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL23064481 | 0.76 | ACHE (0.47) | ACHEDDB1CRBNLMNAL3MBTL1 | |
| SCHEMBL27868018 | 0.76 | HTR2C (0.47) | ACHEDDB1CRBNLMNA | |
| SCHEMBL28533812 | 0.75 | CHRM5 (0.44) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL28946621 | 0.75 | CHRM5 (0.44) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL30078337 | 0.75 | CHRM5 (0.44) | CHRM5CHRM3CHRM2CHRM1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |