Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24737114 | 0.88 | KEAP1 (0.41) | TAAR1KMT2AMAPK1MEN1CHRM5 | |
| SCHEMBL23323167 | 0.84 | TAAR1 (0.37) | DRD2DRD3TAAR1KMT2AMEN1 | |
| SCHEMBL28907793 | 0.82 | ACHE (0.40) | TAAR1KMT2ALMNAMAPTMEN1 | |
| SCHEMBL23487421 | 0.82 | CHRM5 (0.36) | TAAR1KMT2AMEN1CHRM5CHRM3 | |
| SCHEMBL28533132 | 0.82 | PIM1 (0.37) | TAAR1KMT2AMEN1CHRM5CHRM3 | |
| SCHEMBL24853469 | 0.80 | TAAR1 (0.40) | DRD2DRD3TAAR1KMT2AMEN1 | |
| SCHEMBL28527431 | 0.79 | TAAR1 (0.43) | TAAR1KMT2AMEN1CHRM5CHRM3 | |
| SCHEMBL28527428 | 0.79 | TAAR1 (0.43) | TAAR1KMT2AMEN1CHRM5CHRM3 | |
| SCHEMBL28537464 | 0.79 | TAAR1 (0.43) | TAAR1KMT2AMEN1CHRM5CHRM3 | |
| SCHEMBL28907801 | 0.78 | GPR119 (0.48) | LMNAMAPTMAPK1KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |