SCHEMBL2474536

SCHEMBL2474536

C#Cc1ccc2cc(O)ccc2c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.50
ESR2 Q92731 10/20 0.46
ESR1 P03372 9/20 0.46
CYP3A4 P08684 2/20 0.46
ALOX15 P16050 1/20 0.46
TSHR P16473 1/20 0.46
HIF1A Q16665 1/20 0.46
HSD17B10 Q99714 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
CYP1A1 P04798 1/20 0.43
CYP1B1 Q16678 1/20 0.43
ABL1 P00519 1/20 0.43
ABCB1 P08183 1/20 0.43
BCR P11274 1/20 0.43
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
HSD17B1 P14061 1/20 0.42
CYP2B6 P20813 1/20 0.42
CYP2C19 P33261 1/20 0.42
HSD17B2 P37059 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29624584 1.00 CYP1A2 (0.50) CYP1A2ESR2ESR1CYP3A4ALOX15
SCHEMBL1478481 0.85 CYP1A1 (0.54) CYP1A2CYP1A1CYP1B1
SCHEMBL29870412 0.85 CYP1A1 (0.54) CYP1A2CYP1A1CYP1B1
SCHEMBL10481157 0.83 CYP1A1 (0.52) CYP1A1CYP1B1
SCHEMBL21741209 0.81 CYP1A2 (0.54) CYP1A2ESR2ESR1CYP3A4ALOX15
SCHEMBL29203830 0.80 CYP1A1 (0.50) CYP3A4ALOX15HIF1AHSD17B10TDP1
SCHEMBL21967023 0.79 CYP1A2 (0.52) CYP1A2ESR2ESR1CYP3A4ALOX15
SCHEMBL12986899 0.78 CYP1A1 (0.52) CYP1A2CYP1A1CYP1B1
SCHEMBL29832259 0.78 CYP1A1 (0.52) CYP1A2CYP1A1CYP1B1
SCHEMBL31453310 0.77 CA2 (0.58) CYP1A2ESR2ESR1CYP3A4ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3632983-B1 POLYCARBONATE RESIN COMPOSITION, MOLDED ARTICLE, POLYCARBONATE RESIN, AND TERMINAL-BLOCKING AGENT FOR POLYCARBONATE RESIN MITSUBISHI GAS CHEMICAL CO (JP) 2022-08-10 EP disclosed
US-11370883-B2 Polycarbonate resin composition, molded article, polycarbonate resin, and end-capping agent for polycarbonate resin MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2022-06-28 US disclosed
US-11370883-B2 Polycarbonate resin composition, molded article, polycarbonate resin, and end-capping agent for polycarbonate resin MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2022-06-28 US disclosed
CN-110709469-B Polycarbonate resin composition, molded article, polycarbonate resin, and end-capping agent for polycarbonate resin 三菱瓦斯化学株式会社 2022-04-29 CN disclosed
US-20210355409-A1 PHOTOLUMINESCENT LUBRICATING GREASE COMPOSITION, PHOTOLUMINESCENT MATERIAL AND THE PREPARATION METHODS THEREOF CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2021-11-18 US disclosed
US-20200115496-A1 POLYCARBONATE RESIN COMPOSITION, MOLDED ARTICLE, POLYCARBONATE RESIN, AND END-CAPPING AGENT FOR POLYCARBONATE RESIN MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2020-04-16 US disclosed
EP-3632983-A1 POLYCARBONATE RESIN COMPOSITION, MOLDED ARTICLE, POLYCARBONATE RESIN, AND TERMINAL-BLOCKING AGENT FOR POLYCARBONATE RESIN Mitsubishi Gas Chemical Company, Inc. (JP) 2020-04-08 EP disclosed
CN-110709469-A Polycarbonate resin composition, molded article, polycarbonate resin, and end-capping agent for polycarbonate resin 三菱瓦斯化学株式会社 2020-01-17 CN disclosed
EP-2373163-B1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE GENENTECH INC (US) 2015-06-10 EP disclosed
EP-2373163-B1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE GENENTECH INC (US) 2015-06-10 EP disclosed
US-20100210622-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE ABBVIE INC. 2010-08-19 US disclosed
WO-2010080503-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2010-07-15 WO disclosed
WO-2010080503-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2010-07-15 WO disclosed
US-20030065117-A1 Modified silicone compound, process of producing the same, and cured object obtained therefrom NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2003-04-03 US disclosed
EP-0793656-B1 NOVEL BENZYL PYRIMIDINES BASILEA PHARMACEUTICA AG (CH) 2003-03-26 EP disclosed
EP-0834499-B1 Process for the preparation of aromatic vinyl compounds DAINIPPON INK & CHEMICALS (JP) 2001-07-25 EP disclosed
US-5763450-A BACTERICIDES; TREATMENT OF INFECTIOUS DISEASES HOFFMANN-LA ROCHE INC. (US) 1998-06-09 US disclosed
EP-0834499-A1 Process for the preparation of aromatic vinyl compounds DAINIPPON INK AND CHEMICALS, INC. (JP) 1998-04-08 EP disclosed
EP-0793656-A1 NOVEL BENZYL PYRIMIDINES F. HOFFMANN-LA ROCHE AG (CH) 1997-09-10 EP disclosed
WO-1996016046-A2 NOVEL BENZYL PYRIMIDINES F. HOFFMANN-LA ROCHE AG (CH) 1996-05-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200115496-A1 POLYCARBONATE RESIN COMPOSITION, MOLDED ARTICLE, POLYCARBONATE RESIN, AND END-CAPPING AGENT FOR POLYCARBONATE RESIN CAPZA1, RNGTT, RPP30 CYP1A2 4125/4885ESR2 2299/4885ESR1 2484/4885
US-20100210622-A1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE BCL2A1, BAX, BCL2 CYP1A2 360/4885ESR2 260/4885ESR1 415/4885
US-20210355409-A1 PHOTOLUMINESCENT LUBRICATING GREASE COMPOSITION, PHOTOLUMINESCENT MATERIAL AND THE PREPARATION METHODS THEREOF TPSD1, TPSG1, TPSB2 CYP1A2 1616/4885ESR2 663/4885ESR1 879/4885
US-11370883-B2 Polycarbonate resin composition, molded article, polycarbonate resin, and end-capping agent for polycarbonate resin CAPZA1, RNGTT, RPP30 CYP1A2 4125/4885ESR2 2299/4885ESR1 2484/4885
US-20030065117-A1 Modified silicone compound, process of producing the same, and cured object obtained therefrom ORMDL3, SGMS1, HEATR1 CYP1A2 3650/4885ESR2 961/4885ESR1 758/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.