Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ECE1 | P42892 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829792 | 0.84 | ITGB3 (0.49) | ACE | |
| SCHEMBL10769022 | 0.84 | ITGB3 (0.49) | ACEMMENPSR1ECE1LMNA | |
| SCHEMBL9829783 | 0.84 | ITGB3 (0.49) | ACE | |
| SCHEMBL9829868 | 0.84 | SLC6A9 (0.45) | ACELMNA | |
| SCHEMBL9829848 | 0.84 | SLC6A9 (0.45) | ACELMNA | |
| SCHEMBL8255755 | 0.83 | MME (0.50) | MMENPSR1NAALAD2 | |
| SCHEMBL5870135 | 0.83 | MME (0.50) | MMENPSR1NAALAD2 | |
| SCHEMBL29448215 | 0.83 | MME (0.43) | MMENPSR1NAALAD2 | |
| SCHEMBL30659881 | 0.83 | OPRD1 (0.48) | — | |
| SCHEMBL9665688 | 0.82 | ERCC1 (0.39) | ACELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2371421-A1 | Ligands of insulin degrading enzyme and their uses | Université de Lille 2 Droit et Santé (FR) | 2011-10-05 | — | — | EP | disclosed |